-transparent.png){kind=logo}
Current practice with digoxin was assessed in a group of 42 elderly patients by comparing plasma digoxin concentrations attained on previously established maintenance doses with those generated by a computer programme designed to calculate dosage schedules to suit individual patients. Discrepancies between measured and computed plasma levels and between established and computed doses dictated withdrawal of the drug or revision of dosage in 26 patients (62%), with obvious clinical benefit. An important determinant of dosage was renal function; reduction in creatinine clearance provided good evidence for the loss of ability of the elderly kidney to eliminate digoxin. Simple bedside methods are available which permit a reliable estimate of creatinine clearance without a 24-hour urine collection, provoding a rational basis for the choice of digoxin dosage in the elderly.
B Whiting, and
I Wandless, and
D J Sumner, and
A Goldberg
August 1973,
The New England journal of medicine,
B Whiting, and
I Wandless, and
D J Sumner, and
A Goldberg
May 1975,
Annals of internal medicine,
B Whiting, and
I Wandless, and
D J Sumner, and
A Goldberg
November 1988,
RN,
B Whiting, and
I Wandless, and
D J Sumner, and
A Goldberg
November 1985,
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics,
B Whiting, and
I Wandless, and
D J Sumner, and
A Goldberg
January 1990,
Nursing times,
B Whiting, and
I Wandless, and
D J Sumner, and
A Goldberg
January 2011,
Geriatric nursing (New York, N.Y.),
B Whiting, and
I Wandless, and
D J Sumner, and
A Goldberg
January 1974,
Gerontologia clinica,
B Whiting, and
I Wandless, and
D J Sumner, and
A Goldberg
January 2016,
Advances in gerontology = Uspekhi gerontologii,
B Whiting, and
I Wandless, and
D J Sumner, and
A Goldberg
January 2005,
Krankenpflege Journal,
B Whiting, and
I Wandless, and
D J Sumner, and
A Goldberg
January 2003,
Pathophysiology of haemostasis and thrombosis,
