Biomaterial Database

Effect of pentazocine on renal blood flow. 1978

H Yamashiro

Twenty dogs (weight 8-14 kg) were anaesthetized with sodium pentobarbitone 25 mg per kg body weight and anaesthesia was maintained with nitrous oxide in oxygen. Respiration was controlled with a volume-limited respirator (PaCO2 4.7 +/- 0.4 KPa). Renal blood flow was measured with a square wave electromagnetic flow meter inserted through a left paramedian laparotomy. Renal blood flow decreased transiently following an i.v. injection of pentazocine. The decreases were 81% +/- 10.8 and 77% +/- 3 of the control following the administration of pentazocine 1 mg and 2 mg per kg body weight respectively (P less than 0.01). Renal blood flow returned to control values 10-15 min after the injection of the drug.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D010423	Pentazocine	The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)	Fortral,Lexir,Pentazocine Hydrochloride,Pentazocine Lactate,Talwin,Hydrochloride, Pentazocine,Lactate, Pentazocine
D012039	Regional Blood Flow	The flow of BLOOD through or around an organ or region of the body.	Blood Flow, Regional,Blood Flows, Regional,Flow, Regional Blood,Flows, Regional Blood,Regional Blood Flows
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor