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The properties of multiplication stimulating activity (MSA), an insulin-like growth factor (somatomedin) purified from culture medium conditioned by the BRL 3A rat liver cell line are summarized. The relationship of MSA to somatomedins purified from human and rat plasma are considered. MSA appears to be the predominant somatomedin in fetal rat serum, but a minor component of adult rat somatomedin. In vitro biological effects of MSA and insulin in adipocytes, fibroblasts and chondrocytes are examined to determine whether they are mediated by insulin receptors or insulin-like growth factor receptors. The possible relationship of a primary defect of insulin receptors observed in fibroblasts from a patient with the rare genetic disorder, leprechaunism, to intrauterine growth retardation is discussed.
M M Rechler, and
S P Nissley, and
G L King, and
A C Moses, and
E E Van Obberghen-Schilling, and
J A Romanus, and
A B Knight, and
P A Short, and
R M White
October 1978,
The Australian journal of experimental biology and medical science,
M M Rechler, and
S P Nissley, and
G L King, and
A C Moses, and
E E Van Obberghen-Schilling, and
J A Romanus, and
A B Knight, and
P A Short, and
R M White
March 1978,
Nature,
M M Rechler, and
S P Nissley, and
G L King, and
A C Moses, and
E E Van Obberghen-Schilling, and
J A Romanus, and
A B Knight, and
P A Short, and
R M White
January 2017,
PloS one,
M M Rechler, and
S P Nissley, and
G L King, and
A C Moses, and
E E Van Obberghen-Schilling, and
J A Romanus, and
A B Knight, and
P A Short, and
R M White
January 1997,
Cell proliferation,
M M Rechler, and
S P Nissley, and
G L King, and
A C Moses, and
E E Van Obberghen-Schilling, and
J A Romanus, and
A B Knight, and
P A Short, and
R M White
October 1980,
The Journal of biological chemistry,
M M Rechler, and
S P Nissley, and
G L King, and
A C Moses, and
E E Van Obberghen-Schilling, and
J A Romanus, and
A B Knight, and
P A Short, and
R M White
May 1986,
Molecular and cellular endocrinology,
M M Rechler, and
S P Nissley, and
G L King, and
A C Moses, and
E E Van Obberghen-Schilling, and
J A Romanus, and
A B Knight, and
P A Short, and
R M White
January 1984,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
M M Rechler, and
S P Nissley, and
G L King, and
A C Moses, and
E E Van Obberghen-Schilling, and
J A Romanus, and
A B Knight, and
P A Short, and
R M White
September 1984,
Calcified tissue international,
M M Rechler, and
S P Nissley, and
G L King, and
A C Moses, and
E E Van Obberghen-Schilling, and
J A Romanus, and
A B Knight, and
P A Short, and
R M White
May 2019,
Molecular medicine reports,
M M Rechler, and
S P Nissley, and
G L King, and
A C Moses, and
E E Van Obberghen-Schilling, and
J A Romanus, and
A B Knight, and
P A Short, and
R M White
January 1981,
Journal of supramolecular structure and cellular biochemistry,
