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8 mg of naloxone were administered IV to 14 normal volunteers in a placebo-controlled, double-blind experiment. Plasma levels of beta-endorphin, cortisol, prolactin, growth hormone, HVA and MHPG were determined before and 45 min after administration. Naloxone elicited significant increases in cortisol and MHPG but did not change plasma levels of the other compounds. In an additional experiment on two subjects, 20 mg of naloxone caused elevations of beta-endorphin as well as of cortisol. This parallel increase indicates that the linkage between the secretion of beta-endorphin and ACTH/cortisol may be dose-dependent. The increase in MHPG is in agreement with the hypothesized association of noradrenergic hyperactivity and opiate withdrawal.
D Naber, and
D Pickar, and
G C Davis, and
R M Cohen, and
D C Jimerson, and
M A Elchisak, and
E G Defraites, and
N H Kalin, and
S C Risch, and
M S Buchsbaum
August 1988,
Acta psychiatrica Scandinavica,
D Naber, and
D Pickar, and
G C Davis, and
R M Cohen, and
D C Jimerson, and
M A Elchisak, and
E G Defraites, and
N H Kalin, and
S C Risch, and
M S Buchsbaum
August 1989,
Biological psychiatry,
D Naber, and
D Pickar, and
G C Davis, and
R M Cohen, and
D C Jimerson, and
M A Elchisak, and
E G Defraites, and
N H Kalin, and
S C Risch, and
M S Buchsbaum
January 2004,
Journal of psychiatric research,
D Naber, and
D Pickar, and
G C Davis, and
R M Cohen, and
D C Jimerson, and
M A Elchisak, and
E G Defraites, and
N H Kalin, and
S C Risch, and
M S Buchsbaum
February 1993,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
D Naber, and
D Pickar, and
G C Davis, and
R M Cohen, and
D C Jimerson, and
M A Elchisak, and
E G Defraites, and
N H Kalin, and
S C Risch, and
M S Buchsbaum
May 2005,
Addictive behaviors,
D Naber, and
D Pickar, and
G C Davis, and
R M Cohen, and
D C Jimerson, and
M A Elchisak, and
E G Defraites, and
N H Kalin, and
S C Risch, and
M S Buchsbaum
June 1988,
Clinical neuropharmacology,
D Naber, and
D Pickar, and
G C Davis, and
R M Cohen, and
D C Jimerson, and
M A Elchisak, and
E G Defraites, and
N H Kalin, and
S C Risch, and
M S Buchsbaum
January 1996,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
D Naber, and
D Pickar, and
G C Davis, and
R M Cohen, and
D C Jimerson, and
M A Elchisak, and
E G Defraites, and
N H Kalin, and
S C Risch, and
M S Buchsbaum
July 1980,
Endocrinology,
D Naber, and
D Pickar, and
G C Davis, and
R M Cohen, and
D C Jimerson, and
M A Elchisak, and
E G Defraites, and
N H Kalin, and
S C Risch, and
M S Buchsbaum
August 1989,
Acta endocrinologica,
D Naber, and
D Pickar, and
G C Davis, and
R M Cohen, and
D C Jimerson, and
M A Elchisak, and
E G Defraites, and
N H Kalin, and
S C Risch, and
M S Buchsbaum
April 1984,
European journal of pharmacology,
