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In the Salmonella/microsome plate or liquid assay, the addition of glutathione (GSH) and uridine 5'-diphosphoglucuronic acid (UDPGA), both cofactors for GSH-S-transferases or UDPGA-transferases, altered the rat-liver microsome-mediated mutagenesis of benzo[a]pyrene (BP) and aflatoxin B1 (AFB). With either BP or AFB, an increased, unchanged or decreased number of revertant colonies of S. typhimurium was observed, depending on the substrate concentration, the source of rat-liver 9000 X g supernatant (S9), the time of incubation and the type of mutagenicity test (liquid or plate assay). Several factors responsible for quantitative changes in the pattern of BP and AFB metabolites under various assay conditions in vitro, which alter the overall mutagenic activity of the parent compound, are discussed.
C Malaveille, and
G Brun, and
A Hautefeuille, and
H Bartsch
November 1977,
Cancer research,
C Malaveille, and
G Brun, and
A Hautefeuille, and
H Bartsch
March 1980,
Mutation research,
C Malaveille, and
G Brun, and
A Hautefeuille, and
H Bartsch
December 1974,
Cancer research,
C Malaveille, and
G Brun, and
A Hautefeuille, and
H Bartsch
January 1979,
Environmental mutagenesis,
C Malaveille, and
G Brun, and
A Hautefeuille, and
H Bartsch
January 1987,
Environmental mutagenesis,
C Malaveille, and
G Brun, and
A Hautefeuille, and
H Bartsch
July 1990,
Cancer letters,
C Malaveille, and
G Brun, and
A Hautefeuille, and
H Bartsch
July 1979,
Mutation research,
C Malaveille, and
G Brun, and
A Hautefeuille, and
H Bartsch
March 1994,
Comparative biochemistry and physiology. Pharmacology, toxicology and endocrinology,
C Malaveille, and
G Brun, and
A Hautefeuille, and
H Bartsch
January 1981,
Environmental mutagenesis,
C Malaveille, and
G Brun, and
A Hautefeuille, and
H Bartsch
March 1982,
Journal of pharmacological methods,
