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The adrenocorticotropin fragment ACTH/MSH 4--10 (0.1 ug/kg IP) effectively modulates the neuromuscular responses of 9 to 15 day old rats. Muscle (extensor digitorum longus) contraction amplitude is increased, fatigue is delayed and muscle half-relaxation time is shortened during 20 min of continuous in situ stimulation of a branch of the deep peroneal nerve (square wave shocks 10 Hz, duration 0.5 msec, strength supermaximal). No effect on contraction time is seen. There is no facilitation or change in any contraction parameter in rats older than two weeks (16 to 40 days) indicating that these older animals, like normal adult rats, are unaffected by the peptide. Immature rats, however, are even more sensitive than hypophysectomized adult rats [29] to the ameliorative action of ACTH/MSH 4-10. This early sensitivity to ACTH/MSH 4--10 corresponds to important developmental changes occurring in nerve and muscle during the most critical period in postnatal development, the first two weeks.
C M Smith, and
F L Strand
January 1981,
Peptides,
C M Smith, and
F L Strand
January 1988,
Peptides,
C M Smith, and
F L Strand
July 1988,
Trends in pharmacological sciences,
C M Smith, and
F L Strand
January 1987,
International journal of neurology,
C M Smith, and
F L Strand
October 1975,
Physiology & behavior,
C M Smith, and
F L Strand
January 1985,
Peptides,
C M Smith, and
F L Strand
January 1976,
Pharmacology, biochemistry, and behavior,
C M Smith, and
F L Strand
May 1977,
The Journal of clinical endocrinology and metabolism,
C M Smith, and
F L Strand
January 1982,
Peptides,
C M Smith, and
F L Strand
January 1986,
Peptides,
