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Exogenous prostaglandins E1 and E2 and L-isoproterenol potently inhibited the production of superoxide anions by human neutrophils activated in vitro by n-formylmethionyl-leucyl-phenylalanine (FMLP). An estimated ID50 of 50 nM was found for all three agents while L-epinephrine and prostaglandin F2 alpha were 10 and 100 fold, respectively, less active. Inhibition occurred whether these agents were added before, together with, or after the addition of the tripeptide to cell suspensions. Cells treated with dibutyryl adenosine 3',5'-monophosphate also expressed reduced rates of superoxide synthesis thus suggesting that the hormonal inhibitors acted indirectly by stimulating membrane bound adenylate cyclase.
K Wong, and
K Freund
March 1999,
The Journal of pharmacy and pharmacology,
K Wong, and
K Freund
January 1997,
Free radical biology & medicine,
K Wong, and
K Freund
April 1984,
Agents and actions,
K Wong, and
K Freund
April 1994,
The Biochemical journal,
K Wong, and
K Freund
April 1983,
Agents and actions,
K Wong, and
K Freund
January 1985,
Infection and immunity,
K Wong, and
K Freund
May 1997,
Biochemical pharmacology,
K Wong, and
K Freund
July 1982,
Immunology letters,
K Wong, and
K Freund
February 1989,
Inflammation,
K Wong, and
K Freund
December 1981,
Infection and immunity,
