Synthesis and biological activity of two disulphide bond isomers of human insulin: [A7-A11,A6-B7-cystine]- and [A6-A7,A11-B7-cystine]insulin (human). 1978

P Sieber, and K Eisler, and B Kamber, and B Riniker, and W Rittel, and F Märki, and M de Gasparo

UI MeSH Term Description Entries
D007003 Hypoglycemia A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH. Fasting Hypoglycemia,Postabsorptive Hypoglycemia,Postprandial Hypoglycemia,Reactive Hypoglycemia,Hypoglycemia, Fasting,Hypoglycemia, Postabsorptive,Hypoglycemia, Postprandial,Hypoglycemia, Reactive
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D007525 Isoelectric Focusing Electrophoresis in which a pH gradient is established in a gel medium and proteins migrate until they reach the site (or focus) at which the pH is equal to their isoelectric point. Electrofocusing,Focusing, Isoelectric
D007536 Isomerism The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed) Isomerisms
D008297 Male Males
D002621 Chemistry A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
D002850 Chromatography, Gel Chromatography on non-ionic gels without regard to the mechanism of solute discrimination. Chromatography, Exclusion,Chromatography, Gel Permeation,Chromatography, Molecular Sieve,Gel Filtration,Gel Filtration Chromatography,Chromatography, Size Exclusion,Exclusion Chromatography,Gel Chromatography,Gel Permeation Chromatography,Molecular Sieve Chromatography,Chromatography, Gel Filtration,Exclusion Chromatography, Size,Filtration Chromatography, Gel,Filtration, Gel,Sieve Chromatography, Molecular,Size Exclusion Chromatography
D002855 Chromatography, Thin Layer Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Chromatography, Thin-Layer,Thin Layer Chromatography,Chromatographies, Thin Layer,Chromatographies, Thin-Layer,Thin Layer Chromatographies,Thin-Layer Chromatographies,Thin-Layer Chromatography
D003377 Countercurrent Distribution A method of separation of two or more substances by repeated distribution between two immiscible liquid phases that move past each other in opposite directions. It is a form of liquid-liquid chromatography. (Stedman, 25th ed) Chromatography, Countercurrent,Countercurrent Chromatography,Distribution, Countercurrent
D003553 Cystine A covalently linked dimeric nonessential amino acid formed by the oxidation of CYSTEINE. Two molecules of cysteine are joined together by a disulfide bridge to form cystine. Copper Cystinate,L-Cystine,L Cystine

Related Publications

P Sieber, and K Eisler, and B Kamber, and B Riniker, and W Rittel, and F Märki, and M de Gasparo
January 2004, Journal of biochemistry,
P Sieber, and K Eisler, and B Kamber, and B Riniker, and W Rittel, and F Märki, and M de Gasparo
December 2017, Scientific reports,
P Sieber, and K Eisler, and B Kamber, and B Riniker, and W Rittel, and F Märki, and M de Gasparo
February 2024, Journal of peptide science : an official publication of the European Peptide Society,
P Sieber, and K Eisler, and B Kamber, and B Riniker, and W Rittel, and F Märki, and M de Gasparo
July 2018, The Journal of biological chemistry,
P Sieber, and K Eisler, and B Kamber, and B Riniker, and W Rittel, and F Märki, and M de Gasparo
August 1996, Biochimica et biophysica acta,
P Sieber, and K Eisler, and B Kamber, and B Riniker, and W Rittel, and F Märki, and M de Gasparo
May 1974, Biochemistry,
P Sieber, and K Eisler, and B Kamber, and B Riniker, and W Rittel, and F Märki, and M de Gasparo
December 2019, Journal of medicinal chemistry,
P Sieber, and K Eisler, and B Kamber, and B Riniker, and W Rittel, and F Märki, and M de Gasparo
February 1973, Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
P Sieber, and K Eisler, and B Kamber, and B Riniker, and W Rittel, and F Märki, and M de Gasparo
January 1980, International journal of peptide and protein research,
P Sieber, and K Eisler, and B Kamber, and B Riniker, and W Rittel, and F Märki, and M de Gasparo
November 1990, Biological chemistry Hoppe-Seyler,
Copied contents to your clipboard!