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The simple life support system of organ culture contrasts sharply with the life support system in vivo. Organ culture, a technique for characterizing the effect of various substances on an organ, has potential clinical usefulness in many areas. In the present case explants of canine prostate are minimally maintained when cultivated in a medium enriched with testosterone and insulin. Pretreatment of the dog with methylprednisolone or the addition of vitamin A markedly improves the maintenance of normal structure. Methylprednisolone pretreatment and the addition of vitamin A had a significant synergistic effect. The clinical significance and implications of the findings are presented. We believe these preliminary experiments with organ culture can serve as a basis for deciphering some of the complex functions or an organ.
K R Herwig, and
T V Fischer, and
W E Burkel, and
R H Kahn
October 1969,
Veterinary medicine, small animal clinician : VM, SAC,
K R Herwig, and
T V Fischer, and
W E Burkel, and
R H Kahn
January 1980,
Progress in clinical and biological research,
K R Herwig, and
T V Fischer, and
W E Burkel, and
R H Kahn
January 1974,
Research in veterinary science,
K R Herwig, and
T V Fischer, and
W E Burkel, and
R H Kahn
November 1993,
Cancer research,
K R Herwig, and
T V Fischer, and
W E Burkel, and
R H Kahn
January 1977,
The Journal of endocrinology,
K R Herwig, and
T V Fischer, and
W E Burkel, and
R H Kahn
March 1995,
Microscopy research and technique,
K R Herwig, and
T V Fischer, and
W E Burkel, and
R H Kahn
June 1987,
The Anatomical record,
K R Herwig, and
T V Fischer, and
W E Burkel, and
R H Kahn
May 1975,
The Journal of endocrinology,
K R Herwig, and
T V Fischer, and
W E Burkel, and
R H Kahn
July 1976,
Investigative urology,
K R Herwig, and
T V Fischer, and
W E Burkel, and
R H Kahn
September 1970,
The Journal of endocrinology,
