Biomaterial Database

Intrarenal hemodynamics and renal function in postobstructive uropathy. 1978

C H Hsu, and T W Kurtz, and J Rosenzweig, and J M Weller

Impairment of renal function was noted after release of 24 hr of unilateral (UUO) and bilateral (BUO) ureteral obstruction. After release of obstruction fractional sodium excretion was identical in both obstructed and intact kidney of UUO rats, whereas massive natriuresis occurred in BUO rats. Renal blood flow in BUO rats, determined by the microsphere method after released of 24 h of obstruction, was approximately 60 per cent of control values. Mean renal blood flow of the obstructed kidney of UUO rats after release of obstruction was 78 per cent of the mean renal blood flow of the contralateral unobstructed kidney. No redistribution of intrarenal blood flow was noted in UUO and BUO rats. Filtration fractions of obstructed kidneys from BUO and UUO rats after release of obstruction were lower than those of controls, suggesting that preglomerular vasoconstriction is primarily involved in the reduction of glomerular filtration rate.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008297	Male		Males
D009318	Natriuresis	Sodium excretion by URINATION.	Natriureses
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D012039	Regional Blood Flow	The flow of BLOOD through or around an organ or region of the body.	Blood Flow, Regional,Blood Flows, Regional,Flow, Regional Blood,Flows, Regional Blood,Regional Blood Flows
D003404	Creatinine		Creatinine Sulfate Salt,Krebiozen,Salt, Creatinine Sulfate,Sulfate Salt, Creatinine
D004231	Diuresis	An increase in the excretion of URINE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Diureses
D005919	Glomerular Filtration Rate	The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.	Filtration Rate, Glomerular,Filtration Rates, Glomerular,Glomerular Filtration Rates,Rate, Glomerular Filtration,Rates, Glomerular Filtration
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014517	Ureteral Obstruction	Blockage in any part of the URETER causing obstruction of urine flow from the kidney to the URINARY BLADDER. The obstruction may be congenital, acquired, unilateral, bilateral, complete, partial, acute, or chronic. Depending on the degree and duration of the obstruction, clinical features vary greatly such as HYDRONEPHROSIS and obstructive nephropathy.	Obstruction, Ureteral,Obstructions, Ureteral,Ureteral Obstructions