Biomaterial Database

[Response of several adrenal steroids to rapid ACTH stimulation test in essential hypertension and primary aldosteronism (author's transl)]. 1981

T Suzuki, and K Nakagawa, and T Ito

Plasma concentration of progesterone (P), 17 alpha-hydroxyprogesterone (17 alpha-P), 11-desoxy-cortisol (S), cortisol (F), 11-desoxycorticosterone (DOC), corticosterone (B), aldosterone (ALD), dehydroepiandrosterone-free (DHA-f), dehydroepiandrosterone-sulfate (DHA-s) and testosterone (TEST) were measured in 26 essential hypertension (E.H.) and 6 primary aldosteronism (P.A.) before, 30 min. and 60 min. after the intravenous infusion of ACTH 250 micrograms. Seven E.H. patients were similarly studied in the condition of low and high sodium intake and plasma renin activity (PRA) was also measured at the same time. P.A. showed significantly higher ALD than that of E.H., whereas DHA-f and DHA-s levels of these patients were lower than that of E.H. In men with E.H., TEST level showed step down response to ACTH. Low sodium intake induced a marked increase of ALD and PRA in E.H. In low sodium intake other mineralocorticoids such as DOC and B showed high value at 60 min (20% t value) after ACTh infusion. From these observations, it was suggested that the mineralocorticoids have a good response to ACTh in low sodium intake rather than high sodium intake, especially ALD has a clearly augmented response to ACTh. On the other hand, PRA showed only a reserve response to ACTH infusion.

UI	MeSH Term	Description	Entries
D006973	Hypertension	Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D008297	Male		Males
D011374	Progesterone	The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.	Pregnenedione,Progesterone, (13 alpha,17 alpha)-(+-)-Isomer,Progesterone, (17 alpha)-Isomer,Progesterone, (9 beta,10 alpha)-Isomer
D003900	Desoxycorticosterone	A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE	21-Hydroxyprogesterone,Cortexone,Deoxycorticosterone,Desoxycortone,11-Decorticosterone,21-Hydroxy-4-pregnene-3,20-dione,11 Decorticosterone,21 Hydroxy 4 pregnene 3,20 dione,21 Hydroxyprogesterone
D004039	Diet, Sodium-Restricted	A diet which contains very little sodium chloride. It is prescribed by some for hypertension and for edematous states. (Dorland, 27th ed)	Diet, Low-Salt,Diet, Low-Sodium,Diet, Salt-Free,Diet, Low Salt,Diet, Low Sodium,Diet, Salt Free,Diet, Sodium Restricted,Diets, Low-Salt,Diets, Low-Sodium,Diets, Salt-Free,Diets, Sodium-Restricted,Low-Salt Diet,Low-Salt Diets,Low-Sodium Diet,Low-Sodium Diets,Salt-Free Diet,Salt-Free Diets,Sodium-Restricted Diet,Sodium-Restricted Diets
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006854	Hydrocortisone	The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.	Cortef,Cortisol,Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-,11-Epicortisol,Cortifair,Cortril,Epicortisol,Hydrocortisone, (11 alpha)-Isomer,Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer,11 Epicortisol
D006908	Hydroxyprogesterones	Metabolites or derivatives of PROGESTERONE with hydroxyl group substitution at various sites.
D006929	Hyperaldosteronism	A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.	Aldosteronism,Conn Syndrome,Conn's Syndrome,Primary Hyperaldosteronism,Conns Syndrome,Hyperaldosteronism, Primary,Syndrome, Conn,Syndrome, Conn's