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The observation of two cases of thrombophlebitis of the calf which occurred in two sisters within a period of three years is reported. The investigation revealed in both cases the presence of a circulating anticoagulant with anti-prothrombinase activity in association with biological signs of systemic lupus erythematosus (L.E.): anti-DNA antibodies, decreased complement levels, false positive BW reactions. In one patient, the skin biopsy showed a continuous IgM band on immuno-fluorescence. After respectively 4 years and 18 months follow-up both patients are still free from clinical symptoms. A review of the literature is presented and the clinical and etiological significance of the presence of a circulating anticoagulant, its relationship with L.E., particularly with "latent" L.E. (presence of biological signs only), and its association with thrombophlebitis are discussed.
M L Perraudin, and
A Rousseau, and
J C Desbois, and
A Herrault, and
B Léveque
March 1981,
American journal of diseases of children (1960),
M L Perraudin, and
A Rousseau, and
J C Desbois, and
A Herrault, and
B Léveque
January 1981,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
M L Perraudin, and
A Rousseau, and
J C Desbois, and
A Herrault, and
B Léveque
March 1984,
Lancet (London, England),
M L Perraudin, and
A Rousseau, and
J C Desbois, and
A Herrault, and
B Léveque
October 1986,
The Journal of rheumatology,
M L Perraudin, and
A Rousseau, and
J C Desbois, and
A Herrault, and
B Léveque
January 1985,
Revue neurologique,
M L Perraudin, and
A Rousseau, and
J C Desbois, and
A Herrault, and
B Léveque
January 1987,
The American journal of the medical sciences,
M L Perraudin, and
A Rousseau, and
J C Desbois, and
A Herrault, and
B Léveque
June 1986,
Archives of internal medicine,
M L Perraudin, and
A Rousseau, and
J C Desbois, and
A Herrault, and
B Léveque
January 1965,
Polskie Archiwum Medycyny Wewnetrznej,
M L Perraudin, and
A Rousseau, and
J C Desbois, and
A Herrault, and
B Léveque
October 1983,
British medical journal (Clinical research ed.),
M L Perraudin, and
A Rousseau, and
J C Desbois, and
A Herrault, and
B Léveque
August 1979,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
