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125I-angiotensin II (125I-AII) binding was examined in the hypothalamic-thalamic-septal-midbrain (HTSM) region of HLA-Wistar rats in the presence of CNS-active agents. Angiotensin I, II, and III and saralasin competed for 125 I-AII binding, whereas structurally unrelated peptides such as arginine and lysine vasopressin, oxytocin, LHRH, TRH, bradykinin, and substance P did not. In contrast, ACTH and neurotensin exhibited a weak, dose-dependent competition for 125 I-AII binding. The relative potencies of AII, AI, neurotensin and ACTH were 100:1:0.1:0.05, respectively. Neurotensin and ACTH competition was not additive with AII suggesting interaction at shared binding sites. Most importantly, a wide variety of other CNS active agents such as methyldopa, naloxone, catecholamines, clondidine, and reserpine, failed to inhibit 125 I-AII binding, thus further defining the specificity of the CNS AII receptor.
F E Cole, and
H L Blakesley, and
K A Graci, and
E D Frohlich, and
A A MacPhee
December 1981,
Science (New York, N.Y.),
F E Cole, and
H L Blakesley, and
K A Graci, and
E D Frohlich, and
A A MacPhee
October 1990,
European journal of pharmacology,
F E Cole, and
H L Blakesley, and
K A Graci, and
E D Frohlich, and
A A MacPhee
September 1990,
European journal of pharmacology,
F E Cole, and
H L Blakesley, and
K A Graci, and
E D Frohlich, and
A A MacPhee
February 1991,
Clinical and experimental pharmacology & physiology,
F E Cole, and
H L Blakesley, and
K A Graci, and
E D Frohlich, and
A A MacPhee
September 1985,
Proceedings of the National Academy of Sciences of the United States of America,
F E Cole, and
H L Blakesley, and
K A Graci, and
E D Frohlich, and
A A MacPhee
April 1995,
Regulatory peptides,
F E Cole, and
H L Blakesley, and
K A Graci, and
E D Frohlich, and
A A MacPhee
November 1994,
Cardiovascular research,
F E Cole, and
H L Blakesley, and
K A Graci, and
E D Frohlich, and
A A MacPhee
March 1992,
Brain research bulletin,
F E Cole, and
H L Blakesley, and
K A Graci, and
E D Frohlich, and
A A MacPhee
December 1993,
Brain research,
F E Cole, and
H L Blakesley, and
K A Graci, and
E D Frohlich, and
A A MacPhee
January 1991,
Endocrinology,
