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Serum angiotensin-converting enzyme (ACE) is elevated in many patients with pulmonary sarcoidosis and has been proposed as a measure of disease activity. The present study was designed to evaluate the possible relationship between serum ACE and direct measures of the intensity of the alveolitis of pulmonary sarcoidosis as measured by bronchoalveolar lavage and gallium-67 (67Ga) scans. To accomplish this, 64 measurements of serum ACE, lavage T lymphocytes, and lung uptake of 67Ga were performed in 41 patients with biopsy-proven sarcoidosis. Elevations of serum ACE were found on at least one occasion in 17 patients (41%). However, serum ACE was found to be a poor predictor of the intensity of alveolitis in sarcoidosis as assessed by the quantitation of bronchoalveolar lavage cells that were T lymphocytes and by 67Ga scanning. Elevated serum ACE did not predict which patients would have elevated proportions of lavage T lymphocytes, which patients would demonstrate increased pulmonary uptake of 67Ga, or which patients would have high-intensity alveolitis as defined by a combination of these criteria. These observations suggest that while serum ACE may be useful in diagnosing sarcoidosis, it does not reflect accurately the intensity of the alveolitis of the pulmonary component of this disease.
C I Schoenberger, and
B R Line, and
B A Keogh, and
G W Hunninghake, and
R G Crystal
November 1982,
Chest,
C I Schoenberger, and
B R Line, and
B A Keogh, and
G W Hunninghake, and
R G Crystal
May 1984,
The American review of respiratory disease,
C I Schoenberger, and
B R Line, and
B A Keogh, and
G W Hunninghake, and
R G Crystal
January 1982,
Thorax,
C I Schoenberger, and
B R Line, and
B A Keogh, and
G W Hunninghake, and
R G Crystal
September 1982,
Radiology,
C I Schoenberger, and
B R Line, and
B A Keogh, and
G W Hunninghake, and
R G Crystal
March 1986,
Sarcoidosis,
C I Schoenberger, and
B R Line, and
B A Keogh, and
G W Hunninghake, and
R G Crystal
July 1985,
The American review of respiratory disease,
C I Schoenberger, and
B R Line, and
B A Keogh, and
G W Hunninghake, and
R G Crystal
March 1979,
Lancet (London, England),
C I Schoenberger, and
B R Line, and
B A Keogh, and
G W Hunninghake, and
R G Crystal
January 1982,
Respiration; international review of thoracic diseases,
C I Schoenberger, and
B R Line, and
B A Keogh, and
G W Hunninghake, and
R G Crystal
April 1981,
The American review of respiratory disease,
C I Schoenberger, and
B R Line, and
B A Keogh, and
G W Hunninghake, and
R G Crystal
December 1986,
Thorax,
