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The mode of action of hepatic nerves on the metabolism of carbohydrates was studied in the rat liver perfused in situ. 1. Electrical stimulation of the nerve bundles around the hepatic artery and the portal vein resulted in an increase of glucose and lactate output, an enhancement of phosphorylase a activity and a decrease of portal flow. 2. Sodium nitroprusside prevented the hemodynamic changes after nerve stimulation without affecting the metabolic alterations. 3. Phentolamine or an extracellular calcium level below 300 mumol x 1(-1) abolished both hemodynamic and metabolic changes after nerve stimulation, while propranolol or atropine were without effect. 4. Norepinephrine infusion mimicked nerve stimulation only at the highly unphysiological concentration of 0.1 microM; it was not effective at a concentration of 0.01 microM, which might be reached in the sinusoidal blood due to an overflow from intrahepatic synapses. The present results suggest that, in rat liver, glycogen breakdown is regulated by alpha-sympathetic nerves directly rather than indirectly via hemodynamic changes or via norepinephrine overflow.
H Hartmann, and
K Beckh, and
K Jungermann
July 1986,
European journal of biochemistry,
H Hartmann, and
K Beckh, and
K Jungermann
March 1974,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
H Hartmann, and
K Beckh, and
K Jungermann
July 1986,
European journal of biochemistry,
H Hartmann, and
K Beckh, and
K Jungermann
May 1986,
Biological chemistry Hoppe-Seyler,
H Hartmann, and
K Beckh, and
K Jungermann
July 1986,
Biological chemistry Hoppe-Seyler,
H Hartmann, and
K Beckh, and
K Jungermann
December 1981,
FEBS letters,
H Hartmann, and
K Beckh, and
K Jungermann
January 1970,
Bollettino della Societa italiana di biologia sperimentale,
H Hartmann, and
K Beckh, and
K Jungermann
February 1976,
Biochemical pharmacology,
H Hartmann, and
K Beckh, and
K Jungermann
June 1979,
Prostaglandins,
H Hartmann, and
K Beckh, and
K Jungermann
February 1984,
Nihon Ika Daigaku zasshi,
