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A recombinant plasmid, pI26, has been constructed by cloning into pBR322 a transforming gene of murine sarcoma virus (a Moloney strain, clone 124, MSV) synthesized by detergent-treated virions. From this plasmid a XbaI-HindIII fragment has been isolated which contains only mos-specific sequences. This mos-specific probe has been used for screening a human gene library cloned in bacteriophage lambda Charon 4A. Of these, 19 clones have been isolated containing mos-related sequences. By physical mapping and molecular hybridization it has been shown that these sequences are neighboured by DNA regions related to Moloney murine leukemia virus. Recombinant phages have also been found containing human inserts related to MLV, not to the mos gene. The possible existence of murine-like endogenous retroviruses in the normal human genome, including that of a sarcoma type, is discussed. By Northern blotting, expression of the cellular c-mos gene has been detected in mouse liver treated with a hepatocarcinogen. The general significance of the suggested model for evaluating the relationship between chemical carcinogenesis and oncogene expression is discussed.
I M Chumakov, and
E R Zabarovsky, and
V S Prassolov, and
V L Mett, and
L L Kisselev
February 1983,
Science (New York, N.Y.),
I M Chumakov, and
E R Zabarovsky, and
V S Prassolov, and
V L Mett, and
L L Kisselev
November 1981,
Journal of virology,
I M Chumakov, and
E R Zabarovsky, and
V S Prassolov, and
V L Mett, and
L L Kisselev
December 1978,
Proceedings of the National Academy of Sciences of the United States of America,
I M Chumakov, and
E R Zabarovsky, and
V S Prassolov, and
V L Mett, and
L L Kisselev
February 1984,
Journal of virology,
I M Chumakov, and
E R Zabarovsky, and
V S Prassolov, and
V L Mett, and
L L Kisselev
January 1980,
Cold Spring Harbor symposia on quantitative biology,
I M Chumakov, and
E R Zabarovsky, and
V S Prassolov, and
V L Mett, and
L L Kisselev
December 1980,
Cell,
I M Chumakov, and
E R Zabarovsky, and
V S Prassolov, and
V L Mett, and
L L Kisselev
September 1978,
Proceedings of the National Academy of Sciences of the United States of America,
I M Chumakov, and
E R Zabarovsky, and
V S Prassolov, and
V L Mett, and
L L Kisselev
March 1985,
Journal of virology,
I M Chumakov, and
E R Zabarovsky, and
V S Prassolov, and
V L Mett, and
L L Kisselev
January 1987,
Microbiology and immunology,
I M Chumakov, and
E R Zabarovsky, and
V S Prassolov, and
V L Mett, and
L L Kisselev
January 1980,
Oncology,
