Biomaterial Database

Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virus. 1982

N Kitamura, and A Kitamura, and K Toyoshima, and Y Hirayama, and M Yoshida

From the complete nucleotide sequence of the genome of the avian sarcoma virus Y73, we have predicted amino acid sequence of p90 gag-yes, the product of the transforming gene. Contrary to previous evidence from molecular hybridization studies p90 gag-yes was found to have much homology with the transforming gene product p60 src of Rous sarcoma virus, suggesting that the cellular counterparts of the two (c-yes and c-src) originated from a common prototype sequence.

UI	MeSH Term	Description	Entries
D002472	Cell Transformation, Viral	An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.	Transformation, Viral Cell,Viral Cell Transformation,Cell Transformations, Viral,Transformations, Viral Cell,Viral Cell Transformations
D004279	DNA, Viral	Deoxyribonucleic acid that makes up the genetic material of viruses.	Viral DNA
D005814	Genes, Viral	The functional hereditary units of VIRUSES.	Viral Genes,Gene, Viral,Viral Gene
D000595	Amino Acid Sequence	The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.	Protein Structure, Primary,Amino Acid Sequences,Sequence, Amino Acid,Sequences, Amino Acid,Primary Protein Structure,Primary Protein Structures,Protein Structures, Primary,Structure, Primary Protein,Structures, Primary Protein
D001355	Alpharetrovirus	A genus of the family RETROVIRIDAE with type C morphology, that causes malignant and other diseases in wild birds and domestic fowl.	Avian Erythroblastosis Virus,Retroviruses Type C, Avian,Type C Avian Retroviruses,Avian Leukosis-Sarcoma Viruses,Erythroblastosis Virus, Avian,Retroviruses, ALV-Related,ALV-Related Retrovirus,ALV-Related Retroviruses,Alpharetroviruses,Avian Erythroblastosis Viruses,Avian Leukosis Sarcoma Viruses,Avian Leukosis-Sarcoma Virus,Erythroblastosis Viruses, Avian,Leukosis-Sarcoma Virus, Avian,Leukosis-Sarcoma Viruses, Avian,Retrovirus, ALV-Related,Retroviruses, ALV Related,Virus, Avian Erythroblastosis,Virus, Avian Leukosis-Sarcoma,Viruses, Avian Erythroblastosis,Viruses, Avian Leukosis-Sarcoma
D001483	Base Sequence	The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.	DNA Sequence,Nucleotide Sequence,RNA Sequence,DNA Sequences,Base Sequences,Nucleotide Sequences,RNA Sequences,Sequence, Base,Sequence, DNA,Sequence, Nucleotide,Sequence, RNA,Sequences, Base,Sequences, DNA,Sequences, Nucleotide,Sequences, RNA
D014764	Viral Proteins	Proteins found in any species of virus.	Gene Products, Viral,Viral Gene Products,Viral Gene Proteins,Viral Protein,Protein, Viral,Proteins, Viral
D015683	Gene Products, gag	Proteins coded by the retroviral gag gene. The products are usually synthesized as protein precursors or POLYPROTEINS, which are then cleaved by viral proteases to yield the final products. Many of the final products are associated with the nucleoprotein core of the virion. gag is short for group-specific antigen.	Viral gag Proteins,gag Antigen,gag Gene Product,gag Gene Products,gag Polyproteins,gag Protein,gag Viral Proteins,Gene Product, gag,Retroviral Antigen gag Protein,gag Antigens,gag Gene Related Protein,gag Polyprotein,Antigen, gag,Antigens, gag,Polyprotein, gag,Polyproteins, gag,Protein, gag,Proteins, Viral gag,Proteins, gag Viral,Viral Proteins, gag,gag Proteins, Viral
D015688	Oncogene Protein pp60(v-src)	A tyrosine-specific protein kinase encoded by the v-src oncogene of ROUS SARCOMA VIRUS. The transforming activity of pp60(v-src) depends on both the lack of a critical carboxy-terminal tyrosine phosphorylation site at position 527, and the attachment of pp60(v-src) to the plasma membrane which is accomplished by myristylation of its N-terminal glycine.	Oncogene Protein pp60(src),pp60(v-src),src Oncogene Protein pp60,v-src Protein pp60,Avian Sarcoma Virus-Transforming Protein,Oncogene Protein src,Phosphoprotein pp60(v-src),Rous Sarcoma Virus-Transforming Protein pp60(v-src),p60(v-src),pp60 v-src,src Oncogene Product pp60,v-src Protein,Avian Sarcoma Virus Transforming Protein,Protein pp60, v-src,Protein src, Oncogene,pp60 v src,pp60, v-src Protein,src, Oncogene Protein,v src Protein,v src Protein pp60,v-src, pp60