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The photosynthesis of previtamin D3 from 7-dehydrocholesterol in human skin was determined after exposure to narrow-band radiation or simulated solar radiation. The optimum wavelengths for the production of previtamin D3 were determined to be between 295 and 300 nanometers. When human skin was exposed to 295-nanometer radiation, up to 65 percent of the original 7-dehydrocholesterol content was converted to previtamin D3. In comparison, when adjacent skin was exposed to simulated solar radiation, the maximum formation of previtamin D3 was about 20 percent. Major differences in the formation of lumisterol3, and tachysterol3 from previtamin D3 were also observed. It is concluded that the spectral character of natural sunlight has a profound effect on the photochemistry of 7-dehydrocholesterol in human skin.
J A MacLaughlin, and
R R Anderson, and
M F Holick
June 1979,
Nutrition reviews,
J A MacLaughlin, and
R R Anderson, and
M F Holick
February 1981,
Science (New York, N.Y.),
J A MacLaughlin, and
R R Anderson, and
M F Holick
July 1981,
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J A MacLaughlin, and
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M F Holick
July 1993,
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J A MacLaughlin, and
R R Anderson, and
M F Holick
May 2000,
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J A MacLaughlin, and
R R Anderson, and
M F Holick
May 1977,
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J A MacLaughlin, and
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J A MacLaughlin, and
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M F Holick
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Photodermatology, photoimmunology & photomedicine,
J A MacLaughlin, and
R R Anderson, and
M F Holick
January 2010,
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology,
J A MacLaughlin, and
R R Anderson, and
M F Holick
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Bioorganic & medicinal chemistry letters,
