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Deferoxamine-chelatable iron was measured in 103 patients with known or suspected iron overload. All of 34 patients with untreated hemochromatosis had distinctly elevated values for deferoxamine-chelatable iron. The mean value in these cases was significantly greater than that in patients with cirrhosis, who had little or no stainable hepatic iron. In 15 patients with hemochromatosis who were tested sequentially during the course of phlebotomy therapy, deferoxamine-chelatable iron proved a reliable index of the degree of reduction of storage iron. In 22 additional patients with partially treated hemochromatosis and 14 with iron overload accompanying chronic anemia, this test correlated well with the magnitude of iron deposits in liver or bone marrow. In patients with unexplained elevations of serum iron, normal or only slightly elevated deferoxamine-chelatable iron correctly indicated that storage (hepatic) iron was not excessive. The test was more reliable than determination of serum iron or transferrin saturation as an indicator of increased storage iron. Elevated values could not be attributed to disturbed liver function. Determination of deferoxamine-chelatable iron is a safe, practical, and useful procedure for identifying persons with increased iron stores and for assessing the effect of phlebotomy therapy.
W P Baldus, and
V F Fairbanks, and
E R Dickson, and
A H Baggenstoss
January 1990,
Progress in liver diseases,
W P Baldus, and
V F Fairbanks, and
E R Dickson, and
A H Baggenstoss
December 2016,
The Canadian journal of cardiology,
W P Baldus, and
V F Fairbanks, and
E R Dickson, and
A H Baggenstoss
January 1995,
Dermatologic clinics,
W P Baldus, and
V F Fairbanks, and
E R Dickson, and
A H Baggenstoss
September 1981,
Der Internist,
W P Baldus, and
V F Fairbanks, and
E R Dickson, and
A H Baggenstoss
December 1964,
Archives of internal medicine,
W P Baldus, and
V F Fairbanks, and
E R Dickson, and
A H Baggenstoss
August 2008,
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association,
W P Baldus, and
V F Fairbanks, and
E R Dickson, and
A H Baggenstoss
January 1995,
La Revue de medecine interne,
W P Baldus, and
V F Fairbanks, and
E R Dickson, and
A H Baggenstoss
February 2002,
Journal of gastroenterology and hepatology,
W P Baldus, and
V F Fairbanks, and
E R Dickson, and
A H Baggenstoss
January 2018,
Academic pathology,
W P Baldus, and
V F Fairbanks, and
E R Dickson, and
A H Baggenstoss
February 1978,
The New England journal of medicine,
