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The effects of complete ischemia and of in vivo pharmacological treatment with trimetazidine were studied on some enzymatic activities related to energy transduction: lactate dehydrogenase for anaerobic glycolysis; citrate synthase and malate dehydrogenase for the Krebs' cycle; total NADH-cytochrome c reductase and cytochrome oxidase for the electron transport chain; glutamate dehydrogenase for amino acid metabolism and acetylcholine esterase for acetylcholine metabolism. These enzymatic activities were evaluated in brains of 10-day-old rats, at three different subcellular levels: homogenate in toto, purified mitochondrial fraction, crude, synaptosomal fraction. Complete normothermic post-decapitative ischemia of 30 min duration increased the activity of cytochrome oxidase in the homogenate in toto and increased the activities of citrate synthase and malate dehydrogenase in the purified mitochondrial fraction, the activities of the enzymes evaluated in the crude synaptosomal fraction being unaffected. The i.p. treatment with trimetazidine (at the dose level of 50 mg . kg-1) was without any significant effect on the tested enzymatic activities.
D Curti, and
F Marzatico, and
F Dagani, and
R Villa, and
G Benzi
June 1970,
Brain research,
D Curti, and
F Marzatico, and
F Dagani, and
R Villa, and
G Benzi
November 1977,
Journal of neurochemistry,
D Curti, and
F Marzatico, and
F Dagani, and
R Villa, and
G Benzi
April 1987,
Brain research,
D Curti, and
F Marzatico, and
F Dagani, and
R Villa, and
G Benzi
January 1973,
Brain research,
D Curti, and
F Marzatico, and
F Dagani, and
R Villa, and
G Benzi
January 1991,
Neurochemistry international,
D Curti, and
F Marzatico, and
F Dagani, and
R Villa, and
G Benzi
January 1973,
Acta endocrinologica. Supplementum,
D Curti, and
F Marzatico, and
F Dagani, and
R Villa, and
G Benzi
January 1974,
Acta diabetologica latina,
D Curti, and
F Marzatico, and
F Dagani, and
R Villa, and
G Benzi
June 1973,
Archives of biochemistry and biophysics,
D Curti, and
F Marzatico, and
F Dagani, and
R Villa, and
G Benzi
November 1959,
Acta physiologica Scandinavica,
D Curti, and
F Marzatico, and
F Dagani, and
R Villa, and
G Benzi
January 1972,
Zhurnal evoliutsionnoi biokhimii i fiziologii,
