-transparent.png){kind=logo}
We investigated the metabolism of intermediate-density lipoproteins (IDL [1.006 to 1.019 g per milliliter]) and low-density lipoproteins (LDL [1.019 to 1.063 g per milliliter]) in two men with Type III hyperlipoproteinemia associated with myelomatosis. In vivo kinetic studies using radiolabeled autologous lipoproteins demonstrated a greatly reduced fractional catabolic rate of IDL, relative to control values (patients vs. normal, 0.006 and 0.025 per hour vs. 0.20 +/- 0.08 per hour [mean +/- S.E.M]) and a greatly prolonged IDL-to-LDL conversion time (45 and 17 hours vs. 5.4 +/- 1.6 hours). In studies in vitro, LDL from both patients failed to bind to the LDL receptor of normal blood lymphocytes, whereas LDL from subjects with familial Type III hyperlipoproteinemia bound normally to the receptor. In one patient immunoglobulin was shown to be associated with IDL and LDL. Thus, hyperlipoproteinemia reflected an impaired metabolism of IDL, probably secondary to the binding of immunoglobulin to the lipoproteins. A similar impairment of receptor-mediated LDL catabolism did not elevate the plasma LDL concentration because of the low IDL-to-LDL conversion rate.
C Cortese, and
B Lewis, and
N E Miller, and
M A Peyman, and
S N Rao, and
B Slavin, and
U Sule, and
P R Turner, and
G Utermann, and
A J Wing, and
M Weight, and
R Wootton
May 1990,
Klinische Wochenschrift,
C Cortese, and
B Lewis, and
N E Miller, and
M A Peyman, and
S N Rao, and
B Slavin, and
U Sule, and
P R Turner, and
G Utermann, and
A J Wing, and
M Weight, and
R Wootton
April 2002,
Clinical cardiology,
C Cortese, and
B Lewis, and
N E Miller, and
M A Peyman, and
S N Rao, and
B Slavin, and
U Sule, and
P R Turner, and
G Utermann, and
A J Wing, and
M Weight, and
R Wootton
July 1979,
Harefuah,
C Cortese, and
B Lewis, and
N E Miller, and
M A Peyman, and
S N Rao, and
B Slavin, and
U Sule, and
P R Turner, and
G Utermann, and
A J Wing, and
M Weight, and
R Wootton
January 1983,
Vojnosanitetski pregled,
C Cortese, and
B Lewis, and
N E Miller, and
M A Peyman, and
S N Rao, and
B Slavin, and
U Sule, and
P R Turner, and
G Utermann, and
A J Wing, and
M Weight, and
R Wootton
November 1992,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
C Cortese, and
B Lewis, and
N E Miller, and
M A Peyman, and
S N Rao, and
B Slavin, and
U Sule, and
P R Turner, and
G Utermann, and
A J Wing, and
M Weight, and
R Wootton
July 2007,
Nihon rinsho. Japanese journal of clinical medicine,
C Cortese, and
B Lewis, and
N E Miller, and
M A Peyman, and
S N Rao, and
B Slavin, and
U Sule, and
P R Turner, and
G Utermann, and
A J Wing, and
M Weight, and
R Wootton
March 2001,
Nihon rinsho. Japanese journal of clinical medicine,
C Cortese, and
B Lewis, and
N E Miller, and
M A Peyman, and
S N Rao, and
B Slavin, and
U Sule, and
P R Turner, and
G Utermann, and
A J Wing, and
M Weight, and
R Wootton
September 2013,
Nihon rinsho. Japanese journal of clinical medicine,
C Cortese, and
B Lewis, and
N E Miller, and
M A Peyman, and
S N Rao, and
B Slavin, and
U Sule, and
P R Turner, and
G Utermann, and
A J Wing, and
M Weight, and
R Wootton
October 1976,
Deutsche medizinische Wochenschrift (1946),
C Cortese, and
B Lewis, and
N E Miller, and
M A Peyman, and
S N Rao, and
B Slavin, and
U Sule, and
P R Turner, and
G Utermann, and
A J Wing, and
M Weight, and
R Wootton
November 1977,
Annals of internal medicine,
