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Total and superficially exposed plasma membrane components of tumorigenic herpes-simplex-virus (HSV)-transformed fibroblasts were studied. As a result of oncogenic HSV transformation, a significant decrease of polypeptides 230,000, 180,000, 56,000 and 43,000 daltons was found. These changes were accompanied by a significant increase in superficial exposition of several sialopeptides and two peptides of 30,000 and 15,000 daltons. It was suggested that these two peptides may represent virus-coded components of HSV-transformed fibroblasts. The present results indicate that the HSV-transformed tumorigenic cell clone meets all previously described criteria for oncogenically transformed cells.
W Rossowski, and
M Blaszczyk, and
G Darai, and
K Munk
January 1988,
Oncology,
W Rossowski, and
M Blaszczyk, and
G Darai, and
K Munk
January 1975,
IARC scientific publications,
W Rossowski, and
M Blaszczyk, and
G Darai, and
K Munk
April 1984,
Gan,
W Rossowski, and
M Blaszczyk, and
G Darai, and
K Munk
July 1980,
Virology,
W Rossowski, and
M Blaszczyk, and
G Darai, and
K Munk
October 1971,
Journal of virology,
W Rossowski, and
M Blaszczyk, and
G Darai, and
K Munk
September 1976,
The Journal of cell biology,
W Rossowski, and
M Blaszczyk, and
G Darai, and
K Munk
September 1981,
Lipids,
W Rossowski, and
M Blaszczyk, and
G Darai, and
K Munk
April 1982,
Journal of virology,
W Rossowski, and
M Blaszczyk, and
G Darai, and
K Munk
April 1992,
The Journal of general virology,
W Rossowski, and
M Blaszczyk, and
G Darai, and
K Munk
June 1973,
Cancer research,
