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Total cellular poly(A)-enriched RNA from a variety of fresh human leukemic blood cells and hematopoietic cell lines was analyzed for homology with molecularly cloned DNA probes containing the onc sequence of Abelson murine leukemia virus (Ab-MuLV), Harvey murine sarcoma virus (Ha-MuSV), simian sarcoma virus (SSV), and avian myelocytomatosis virus strain MC29. Results with the fresh blood cells paralleled those obtained with the cell lines. With Ab-MuLV and Ha-MuSV, multiple RNA bands were visualized in all cell types examined without significant variation in the relative intensities of the bands. When SSV was used as the probe, expression of related onc sequences was absent in all of the hematopoietic cell types examined except for one neoplastic T-cell line (HUT 102), which produces the human T-cell leukemia (lymphoma) retrovirus HTLV. In this cell line, a single band (4.2 kilobases) was observed. With MC29 as the probe, a single band of 2.7 kilobases was visualized in all cell types examined with only a 10 to 2-fold variation in intensity of hybridization. An exception was the promyelocytic cell line, HL60, which expressed approximately 10-fold more MC29-related onc sequences. With induction of differentiation of HL60 with either dimethyl sulfoxide or retinoic acid, a marked diminution in the amount of the MC29-related, but not the Ab-MuLV-related, onc message was observed.
E H Westin, and
F Wong-Staal, and
E P Gelmann, and
R Dalla-Favera, and
T S Papas, and
J A Lautenberger, and
A Eva, and
E P Reddy, and
S R Tronick, and
S A Aaronson, and
R C Gallo
January 1983,
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E H Westin, and
F Wong-Staal, and
E P Gelmann, and
R Dalla-Favera, and
T S Papas, and
J A Lautenberger, and
A Eva, and
E P Reddy, and
S R Tronick, and
S A Aaronson, and
R C Gallo
January 1987,
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E H Westin, and
F Wong-Staal, and
E P Gelmann, and
R Dalla-Favera, and
T S Papas, and
J A Lautenberger, and
A Eva, and
E P Reddy, and
S R Tronick, and
S A Aaronson, and
R C Gallo
January 1984,
Progress in clinical and biological research,
E H Westin, and
F Wong-Staal, and
E P Gelmann, and
R Dalla-Favera, and
T S Papas, and
J A Lautenberger, and
A Eva, and
E P Reddy, and
S R Tronick, and
S A Aaronson, and
R C Gallo
January 1986,
Princess Takamatsu symposia,
E H Westin, and
F Wong-Staal, and
E P Gelmann, and
R Dalla-Favera, and
T S Papas, and
J A Lautenberger, and
A Eva, and
E P Reddy, and
S R Tronick, and
S A Aaronson, and
R C Gallo
January 2015,
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F Wong-Staal, and
E P Gelmann, and
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J A Lautenberger, and
A Eva, and
E P Reddy, and
S R Tronick, and
S A Aaronson, and
R C Gallo
January 1988,
Society of General Physiologists series,
E H Westin, and
F Wong-Staal, and
E P Gelmann, and
R Dalla-Favera, and
T S Papas, and
J A Lautenberger, and
A Eva, and
E P Reddy, and
S R Tronick, and
S A Aaronson, and
R C Gallo
July 1987,
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E H Westin, and
F Wong-Staal, and
E P Gelmann, and
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J A Lautenberger, and
A Eva, and
E P Reddy, and
S R Tronick, and
S A Aaronson, and
R C Gallo
August 1982,
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E H Westin, and
F Wong-Staal, and
E P Gelmann, and
R Dalla-Favera, and
T S Papas, and
J A Lautenberger, and
A Eva, and
E P Reddy, and
S R Tronick, and
S A Aaronson, and
R C Gallo
January 1983,
Nature,
E H Westin, and
F Wong-Staal, and
E P Gelmann, and
R Dalla-Favera, and
T S Papas, and
J A Lautenberger, and
A Eva, and
E P Reddy, and
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R C Gallo
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Virus genes,
