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This paper describes a monoclonal antibody (B532) that detects a membrane antigen present on greater than or equal to 95% of the B cells from lines carrying the Epstein-Barr virus (EBV) genome. Evidence suggesting that B532 is EBV-related was originally obtained by using a cell-binding radioassay with different cell line substrates. Immunofluorescence and cell-sorter analysis confirmed that the antigen was present in high density on all EBV-infected lymphoblastoid B-cell lines, but not on EBV-negative B-, T-, myeloid, or null cell lines. Isolated normal peripheral blood B and T lymphocytes and monocytes failed to bind B532. The monoclonal antibody did not inhibit in vitro EVB infection nor did it block the killing of EBV-infected targets by cytotoxic T lymphocytes. The cell surface antigen recognized by B532 was shown by immunoprecipitation to have a molecular weight of approximately 45,000.
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I Royston, and
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J H Vaughan
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January 1983,
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S M Baird, and
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J H Vaughan
May 1980,
Proceedings of the National Academy of Sciences of the United States of America,
S F Slovin, and
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D A Carson, and
J H Vaughan
October 1982,
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S F Slovin, and
D M Frisman, and
C D Tsoukas, and
I Royston, and
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S B Wormsley, and
D A Carson, and
J H Vaughan
July 1984,
Proceedings of the National Academy of Sciences of the United States of America,
S F Slovin, and
D M Frisman, and
C D Tsoukas, and
I Royston, and
S M Baird, and
S B Wormsley, and
D A Carson, and
J H Vaughan
January 1987,
Virology,
S F Slovin, and
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I Royston, and
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D A Carson, and
J H Vaughan
March 1984,
Virology,
S F Slovin, and
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I Royston, and
S M Baird, and
S B Wormsley, and
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J H Vaughan
December 1999,
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology,
S F Slovin, and
D M Frisman, and
C D Tsoukas, and
I Royston, and
S M Baird, and
S B Wormsley, and
D A Carson, and
J H Vaughan
June 2015,
Monoclonal antibodies in immunodiagnosis and immunotherapy,
