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Avian myeloblastosis virus is defective in reproductive capacity, requiring a helper virus to provide the viral proteins essential for synthesis of new infectious virus. This virus arose by recombination of the nondefective helper virus and host cellular sequences present within the normal avian genome. These latter sequences are essential for leukemogenic activity. The complete nucleotide sequence of this region is reported. Within the acquired cellular sequences there is an open reading frame of 795 nucleotides starting with the initiation codon ATG (adenine, thymine, guanine) and terminating with the triplet TAG. This open reading frame could code for the putative transforming protein of 265 amino acids with a molecular weight of approximately 30,000.
K E Rushlow, and
J A Lautenberger, and
T S Papas, and
M A Baluda, and
B Perbal, and
J G Chirikjian, and
E P Reddy
January 1983,
Haematology and blood transfusion,
K E Rushlow, and
J A Lautenberger, and
T S Papas, and
M A Baluda, and
B Perbal, and
J G Chirikjian, and
E P Reddy
November 1981,
Journal of virology,
K E Rushlow, and
J A Lautenberger, and
T S Papas, and
M A Baluda, and
B Perbal, and
J G Chirikjian, and
E P Reddy
September 1985,
Virology,
K E Rushlow, and
J A Lautenberger, and
T S Papas, and
M A Baluda, and
B Perbal, and
J G Chirikjian, and
E P Reddy
January 1982,
Journal of virology,
K E Rushlow, and
J A Lautenberger, and
T S Papas, and
M A Baluda, and
B Perbal, and
J G Chirikjian, and
E P Reddy
December 1972,
Archives internationales de physiologie et de biochimie,
K E Rushlow, and
J A Lautenberger, and
T S Papas, and
M A Baluda, and
B Perbal, and
J G Chirikjian, and
E P Reddy
May 1982,
Proceedings of the National Academy of Sciences of the United States of America,
K E Rushlow, and
J A Lautenberger, and
T S Papas, and
M A Baluda, and
B Perbal, and
J G Chirikjian, and
E P Reddy
February 1984,
Journal of virology,
K E Rushlow, and
J A Lautenberger, and
T S Papas, and
M A Baluda, and
B Perbal, and
J G Chirikjian, and
E P Reddy
July 1975,
The Journal of biological chemistry,
K E Rushlow, and
J A Lautenberger, and
T S Papas, and
M A Baluda, and
B Perbal, and
J G Chirikjian, and
E P Reddy
June 1981,
Biochemistry,
K E Rushlow, and
J A Lautenberger, and
T S Papas, and
M A Baluda, and
B Perbal, and
J G Chirikjian, and
E P Reddy
December 1983,
Proceedings of the National Academy of Sciences of the United States of America,
