The purpose of this study was to examine the diagnostic value of sialographic and scintigraphic tests conducted to determine changes in salivary gland function and structure in patients with salivary gland disorders. A simple sialographic technique using a catheter fitted over a lacrimal probe was performed. For optimal pantomographic study of the salivary glands, a slightly oblique view with the head turned to the side was demonstrated to be of value. Examination of the salivary glands by sialography reveals the detailed morphology of the duct system. Sialograms were evaluated for filling and secretory phases and major ducts were also studied morphologically. Clearing radiographs indicated that glands with impaired function have prolonged clearing times. The contrast sialogram is most useful in evaluating recurrent inflammatory disorders, and the radiosialogram finds its greatest value in evaluating patients with suspected neoplasms. These examinations should not be used in lieu of a histologic diagnosis in tumor cases, except when a smooth margined radiopositive lesion corresponding with a clinically evident Warthin's tumor is noted. Perhaps the most important feature of salivary scintigraphy is its sensitivity in depicting changes in glandular dysfunction. In this study objective documentation provided by the scintigraphy closely parallels the results of sialography.