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The hypothesis that prostaglandins participate in beta adrenoreceptor-stimulated renin release was tested by examining the effects of prostaglandin synthesis inhibition on renal nerve stimulation (0.5-5.0 Hz)-induced renin release. In phentolamine (5 micrograms/kg/min, intrarenal artery)-treated dogs (n = 6), renal nerve stimulation produced a frequency-related increase in renal renin secretion rate, without altering renal blood flow. In phentolamine plus propranolol (0.3 mg/kg i.v. bolus + 5 micrograms/kg/min infusion)-treated dogs (n = 6), renal nerve stimulation-induced renin release was inhibited by 86% (P less than .03), 75% (P less than .03) and 73% (P less than .02) at 1, 2 and 5 Hz, respectively. In contrast to propranolol, blockade of prostaglandin synthesis with indomethacin (8 mg/kg i.v. bolus) failed to alter the renin secretory response to renal nerve stimulation in phentolamine-treated animals. These results indicate that, in a situation of intrarenal alpha adrenoreceptor blockade, renal nerve stimulation induces renin secretion by a beta adrenoreceptor mechanism that is independent of prostaglandin biosynthesis.
E K Jackson, and
W A Herzer, and
J B Zimmerman, and
J A Oates, and
R A Branch, and
J F Gerkens
July 1979,
The Journal of pharmacology and experimental therapeutics,
E K Jackson, and
W A Herzer, and
J B Zimmerman, and
J A Oates, and
R A Branch, and
J F Gerkens
December 1978,
Clinical science and molecular medicine. Supplement,
E K Jackson, and
W A Herzer, and
J B Zimmerman, and
J A Oates, and
R A Branch, and
J F Gerkens
June 1975,
Clinical science and molecular medicine. Supplement,
E K Jackson, and
W A Herzer, and
J B Zimmerman, and
J A Oates, and
R A Branch, and
J F Gerkens
February 1972,
Canadian journal of physiology and pharmacology,
E K Jackson, and
W A Herzer, and
J B Zimmerman, and
J A Oates, and
R A Branch, and
J F Gerkens
November 1978,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
E K Jackson, and
W A Herzer, and
J B Zimmerman, and
J A Oates, and
R A Branch, and
J F Gerkens
September 1975,
Life sciences,
E K Jackson, and
W A Herzer, and
J B Zimmerman, and
J A Oates, and
R A Branch, and
J F Gerkens
July 1998,
Journal of the American Society of Nephrology : JASN,
E K Jackson, and
W A Herzer, and
J B Zimmerman, and
J A Oates, and
R A Branch, and
J F Gerkens
October 1977,
Circulation research,
E K Jackson, and
W A Herzer, and
J B Zimmerman, and
J A Oates, and
R A Branch, and
J F Gerkens
January 1977,
Progress in brain research,
E K Jackson, and
W A Herzer, and
J B Zimmerman, and
J A Oates, and
R A Branch, and
J F Gerkens
July 1978,
Clinical science and molecular medicine,
