-transparent.png){kind=logo}
Proteose-peptone-activated mouse macrophages can prevent productive infection by herpes simplex virus in neighboring cells in vitro whether or not those cells belong to the same animal species. The effect does not require contact between the macrophages and the infected cells, may be prevented by adding extra arginine to the medium, and may be reversed when extra arginine is added 24 h after the macrophages. Arginase activity was found both intracellularly and released from the macrophages. The extracellular enzyme is quite stable; 64% activity was found after 48 h of incubation at 37 degrees C in tissue culture medium. No evidence was found that the inefficiency of virus replication in macrophages was due to self-starvation by arginase. As might be predicted macrophages can, by the same mechanism, limit productive infection by vaccinia virus.
P Wildy, and
P G Gell, and
J Rhodes, and
A Newton
May 1965,
Biochimica et biophysica acta,
P Wildy, and
P G Gell, and
J Rhodes, and
A Newton
February 1981,
Cellular immunology,
P Wildy, and
P G Gell, and
J Rhodes, and
A Newton
October 2011,
International journal of molecular medicine,
P Wildy, and
P G Gell, and
J Rhodes, and
A Newton
January 1978,
IARC scientific publications,
P Wildy, and
P G Gell, and
J Rhodes, and
A Newton
June 1980,
Antimicrobial agents and chemotherapy,
P Wildy, and
P G Gell, and
J Rhodes, and
A Newton
January 1975,
Intervirology,
P Wildy, and
P G Gell, and
J Rhodes, and
A Newton
October 1984,
Virology,
P Wildy, and
P G Gell, and
J Rhodes, and
A Newton
October 1985,
The Journal of general virology,
P Wildy, and
P G Gell, and
J Rhodes, and
A Newton
January 1965,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
P Wildy, and
P G Gell, and
J Rhodes, and
A Newton
February 1997,
Pathologie-biologie,
