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The radioprotector with clinical potential, S-2-(3 aminopropylamino)-ethylphosphorothioic acid (WR-2721) is undergoing two Phase I trials. The objectives of these trials are 1) to determine the maximum tolerated dose (MTD) of WR-2721 in a single dose and 2) to determine the highest dose of WR-2721 that can be tolerated daily in the greatest number of fractions per week. A total of 65 patients have been treated. The single maximum tolerated dose has not yet been reached, though 740 mg/m2 is well tolerated. A single dose of 910 mg/m2 has been successfully administered to one patient. The multiple dose MTD is at an early stage with patients currently receiving 170 mg/m2 four times a week. Among the toxicities noted in both trials are hypotension, hypertension, emesis and somnolence. In addition, in the multiple dose trial there have been three patients who have had allergic reactions including one which was life-threatening. Phase II studies are planned and will begin when the maximum tolerated dose is established from each Phase I trial.
A L Blumberg, and
D F Nelson, and
M Gramkowski, and
D Glover, and
J H Glick, and
J M Yuhas, and
M M Kligerman
May 1989,
International journal of radiation oncology, biology, physics,
A L Blumberg, and
D F Nelson, and
M Gramkowski, and
D Glover, and
J H Glick, and
J M Yuhas, and
M M Kligerman
January 1980,
Cancer clinical trials,
A L Blumberg, and
D F Nelson, and
M Gramkowski, and
D Glover, and
J H Glick, and
J M Yuhas, and
M M Kligerman
February 1984,
Radiation research,
A L Blumberg, and
D F Nelson, and
M Gramkowski, and
D Glover, and
J H Glick, and
J M Yuhas, and
M M Kligerman
January 1988,
Pharmacology & therapeutics,
A L Blumberg, and
D F Nelson, and
M Gramkowski, and
D Glover, and
J H Glick, and
J M Yuhas, and
M M Kligerman
January 1990,
Cancer investigation,
A L Blumberg, and
D F Nelson, and
M Gramkowski, and
D Glover, and
J H Glick, and
J M Yuhas, and
M M Kligerman
June 1976,
Radiation research,
A L Blumberg, and
D F Nelson, and
M Gramkowski, and
D Glover, and
J H Glick, and
J M Yuhas, and
M M Kligerman
September 1984,
International journal of radiation oncology, biology, physics,
A L Blumberg, and
D F Nelson, and
M Gramkowski, and
D Glover, and
J H Glick, and
J M Yuhas, and
M M Kligerman
September 1984,
International journal of radiation oncology, biology, physics,
A L Blumberg, and
D F Nelson, and
M Gramkowski, and
D Glover, and
J H Glick, and
J M Yuhas, and
M M Kligerman
January 1988,
Pharmacology & therapeutics,
A L Blumberg, and
D F Nelson, and
M Gramkowski, and
D Glover, and
J H Glick, and
J M Yuhas, and
M M Kligerman
August 1986,
International journal of radiation oncology, biology, physics,
