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Polymorphonuclear leukocytes (PMNs) release superoxide anion (O-2) when they are exposed to a phagocytic stimulus. Intracellularly the copper-containing enzyme superoxide dismutase (SOD) protects against the toxic effects of O-2. To investigate the role of O-2 and SOD in the inflammatory process we determined the O-2 release and SOD content in PMNs. In PMNs of children with rheumatoid arthritis the SOD activity was diminished compared to healthy controls. Upon stimulation with opsonized zymosan PMNs obtained from children with rheumatoid arthritis generated greater amounts of superoxide anion than control cells. The "SOD deficiency" in PMNs of children with rheumatoid arthritis may promote this extreme release of the toxic superoxide radical inducing the damage of the connective tissue. The involvement of superoxide dismutase and superoxide anion in inflammatory process may induce further studies, leading hopefully to an appropriate understanding or even to new principles in the treatment of the rheumatoid arthritis.
M Rister, and
K Bauermeister
January 1975,
Postepy biochemii,
M Rister, and
K Bauermeister
October 1983,
Annals of the rheumatic diseases,
M Rister, and
K Bauermeister
January 1978,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
M Rister, and
K Bauermeister
April 1982,
Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology,
M Rister, and
K Bauermeister
October 1982,
Annals of the rheumatic diseases,
M Rister, and
K Bauermeister
October 2002,
The Journal of rheumatology,
M Rister, and
K Bauermeister
July 1985,
Sheng li ke xue jin zhan [Progress in physiology],
M Rister, and
K Bauermeister
February 1978,
Ryumachi. [Rheumatism],
M Rister, and
K Bauermeister
April 1982,
Horumon to rinsho. Clinical endocrinology,
M Rister, and
K Bauermeister
January 1979,
Journal belge de medecine physique et de rehabilitation. = Belgisch tijdschrift voor fysische geneeskunde en rehabilitatie,
