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To evaluate the role of endogenous opioid peptides in prolactin (Prl), growth hormone (GH) and cortisol neuroregulation, 50 mg of the opiate antagonist naloxone was infused over 24 h to 6 normal male volunteers. An additional naloxone dose (5 mg) was given iv as a bolus injection at 20.00 h. blood specimens were collected hourly by means of a portable constant withdrawal pump. Naloxone failed to alter 24 h secretion of GH and Prl. The sleep-related GH and Prl rise was also unaffected by the opiate blocker. Moreover, naloxone failed to alter the circadian rhythm of cortisol and its 24 h concentration. The results do not suggest, a major role of opiate receptors in spontaneous GH, Prl and cortisol secretion in man.
G Delitala, and
M Giusti, and
G Rodriguez, and
G Mazzocchi, and
S Ferrini, and
L Baccelliere, and
V Montano, and
G Rosadini, and
G Giordano
February 1980,
The Journal of clinical endocrinology and metabolism,
G Delitala, and
M Giusti, and
G Rodriguez, and
G Mazzocchi, and
S Ferrini, and
L Baccelliere, and
V Montano, and
G Rosadini, and
G Giordano
September 1979,
Psychopharmacology,
G Delitala, and
M Giusti, and
G Rodriguez, and
G Mazzocchi, and
S Ferrini, and
L Baccelliere, and
V Montano, and
G Rosadini, and
G Giordano
January 1972,
Journal de physiologie,
G Delitala, and
M Giusti, and
G Rodriguez, and
G Mazzocchi, and
S Ferrini, and
L Baccelliere, and
V Montano, and
G Rosadini, and
G Giordano
July 1978,
Clinical endocrinology,
G Delitala, and
M Giusti, and
G Rodriguez, and
G Mazzocchi, and
S Ferrini, and
L Baccelliere, and
V Montano, and
G Rosadini, and
G Giordano
June 1980,
Clinical endocrinology,
G Delitala, and
M Giusti, and
G Rodriguez, and
G Mazzocchi, and
S Ferrini, and
L Baccelliere, and
V Montano, and
G Rosadini, and
G Giordano
March 1980,
The Journal of clinical endocrinology and metabolism,
G Delitala, and
M Giusti, and
G Rodriguez, and
G Mazzocchi, and
S Ferrini, and
L Baccelliere, and
V Montano, and
G Rosadini, and
G Giordano
January 1980,
Postgraduate medical journal,
G Delitala, and
M Giusti, and
G Rodriguez, and
G Mazzocchi, and
S Ferrini, and
L Baccelliere, and
V Montano, and
G Rosadini, and
G Giordano
July 1976,
The Journal of clinical endocrinology and metabolism,
G Delitala, and
M Giusti, and
G Rodriguez, and
G Mazzocchi, and
S Ferrini, and
L Baccelliere, and
V Montano, and
G Rosadini, and
G Giordano
August 1987,
Regulatory peptides,
G Delitala, and
M Giusti, and
G Rodriguez, and
G Mazzocchi, and
S Ferrini, and
L Baccelliere, and
V Montano, and
G Rosadini, and
G Giordano
January 1988,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
