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The effects of several anaesthetics on spinal cord nociceptive neural mechanisms and their interactions with the opiate antagonist, naloxone, were studied in acute, spinal cord transected cats. Intra-arterial injection of bradykinin was used as the noxious test stimulus. Spontaneous activity and the neural response induced by bradykinin were recorded by the multi-unit activity technique in the lateral funiculus of the spinal cord. Naloxone, 0.1 or 2.0 mg/kg i.v. had little effect on the bradykinin-induced response, but enhanced the spontaneous firing of the lateral funiculus significantly. Fentanyl, 30 micrograms/kg i.v., depressed both the bradykinin-induced response and spontaneous firing. These effects of fentanyl were antagonized completely by naloxone, 0.1 mg/kg i.v. Nitrous oxide, thiamylal, halothane and ether depressed the bradykinin-induced response considerably, but it was not antagonized by naloxone, 0.1-2.0 mg/kg i.v. Enflurane had little effect on the bradykinin-induced response. The effects of these anesthetics on spontaneous firing were divergent: nitrous oxide enhanced it while other drugs depressed it, to various degrees. All these data suggest that the neural and/or neurochemical mechanisms of anesthetic-induced analgesia differ from mechanisms related to opioids.
K Shingu, and
M Osawa, and
Y Omatsu, and
T Komatsu, and
N Urabe, and
K Mori
August 1979,
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K Shingu, and
M Osawa, and
Y Omatsu, and
T Komatsu, and
N Urabe, and
K Mori
June 1978,
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K Shingu, and
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Y Omatsu, and
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K Mori
July 1980,
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K Shingu, and
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K Mori
July 1978,
Anesthesiology,
K Shingu, and
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K Mori
April 1986,
Anesthesia and analgesia,
K Shingu, and
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K Mori
March 1985,
Pain,
K Shingu, and
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January 1989,
Life sciences,
K Shingu, and
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K Shingu, and
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Clinical pharmacology and therapeutics,
K Shingu, and
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K Mori
January 1994,
Anesthesiology,
