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A hepatocellular carcinoma which was predominately black was surgically excised from a noncirrhotic, asymptomatic 62-year-old white man. Brown-black, pigment granules, found only in the tumor cells, were histochemically and ultrastructurally identical to the hepatocellular pigment found in Dubin-Johnson syndrome. The latter pigment is thought to accumulate as a consequence of a genetically determined abnormality in the excretion of catecholamines and related substances. It is postulated that the pigment formation in this tumor developed via a similar, though epigenetic, mechanism. This occurrence has not been previously described. Unusual PAS-negative, globular cytoplasmic inclusions were also found in the tumor cells and these proved to be Mallory bodies by electron microscopy.
J A Roth, and
E Berman, and
D Befeler, and
F B Johnson
April 2017,
International journal of surgical pathology,
J A Roth, and
E Berman, and
D Befeler, and
F B Johnson
December 1966,
Archives d'anatomie pathologique,
J A Roth, and
E Berman, and
D Befeler, and
F B Johnson
January 1960,
Annales d'histochimie,
J A Roth, and
E Berman, and
D Befeler, and
F B Johnson
September 2004,
Journal of gastroenterology,
J A Roth, and
E Berman, and
D Befeler, and
F B Johnson
January 1976,
Archives d'anatomie et de cytologie pathologiques,
J A Roth, and
E Berman, and
D Befeler, and
F B Johnson
January 1971,
Acta pathologica et microbiologica Scandinavica. Section A, Pathology,
J A Roth, and
E Berman, and
D Befeler, and
F B Johnson
January 1972,
Annales de biologie clinique,
J A Roth, and
E Berman, and
D Befeler, and
F B Johnson
January 1965,
Archivio italiano di anatomia e istologia patologica,
J A Roth, and
E Berman, and
D Befeler, and
F B Johnson
January 1963,
Annales d'anatomie pathologique,
J A Roth, and
E Berman, and
D Befeler, and
F B Johnson
November 1971,
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris,
