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Ketoconazole, a broad-spectrum, antifungal drug that is administered orally, has been shown to inhibit sterol synthesis in fungi. When gynecomastia developed in some patients taking this drug, we investigated the effects of ketoconazole on steroid synthesis in humans and in isolated adrenal cells from rats. In healthy humans, the cortisol response to adrenocorticotropic hormone was significantly blunted 4 hours after a 400-mg or 600-mg dose. The inhibition persisted for up to 8 hours and was absent by 16 hours. This finding indicated that adrenal androgen response was reduced. Easily achieved therapeutic concentrations of ketoconazole virtually eliminated corticosterone production by isolated adrenal cells from rats. Although ketoconazole at currently used doses has never been documented to cause clinical hypoadrenalism, caution is urged in high- or multiple-dose trials. The drug may prove useful as an agent to block steroid synthesis.
A Pont, and
P L Williams, and
D S Loose, and
D Feldman, and
R E Reitz, and
C Bochra, and
D A Stevens
May 1983,
The Journal of clinical investigation,
A Pont, and
P L Williams, and
D S Loose, and
D Feldman, and
R E Reitz, and
C Bochra, and
D A Stevens
February 1988,
Zeitschrift fur Hautkrankheiten,
A Pont, and
P L Williams, and
D S Loose, and
D Feldman, and
R E Reitz, and
C Bochra, and
D A Stevens
February 1988,
Clinical and investigative medicine. Medecine clinique et experimentale,
A Pont, and
P L Williams, and
D S Loose, and
D Feldman, and
R E Reitz, and
C Bochra, and
D A Stevens
July 1985,
Klinische Wochenschrift,
A Pont, and
P L Williams, and
D S Loose, and
D Feldman, and
R E Reitz, and
C Bochra, and
D A Stevens
June 1958,
Pediatrics,
A Pont, and
P L Williams, and
D S Loose, and
D Feldman, and
R E Reitz, and
C Bochra, and
D A Stevens
November 1993,
The Clinical investigator,
A Pont, and
P L Williams, and
D S Loose, and
D Feldman, and
R E Reitz, and
C Bochra, and
D A Stevens
February 2003,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
A Pont, and
P L Williams, and
D S Loose, and
D Feldman, and
R E Reitz, and
C Bochra, and
D A Stevens
August 1970,
Recenti progressi in medicina,
A Pont, and
P L Williams, and
D S Loose, and
D Feldman, and
R E Reitz, and
C Bochra, and
D A Stevens
January 1986,
Endocrine research,
A Pont, and
P L Williams, and
D S Loose, and
D Feldman, and
R E Reitz, and
C Bochra, and
D A Stevens
April 1985,
JAMA,
