BIOMAT Database Logo BIOMAT Database Logo

Erythroid progenitors circulating in the blood of adult individuals produce fetal hemoglobin in culture. 1978

T Papayannopoulou, and B Nakamoto, and J Buckley, and S Kurachi, and P E Nute, and G Stamatoyannopoulos

Erythroid colonies, raised from erythroid stem cells circulating in the peripheral blood of normal adult individuals, synthesize considerable amounts of fetal hemoglobin. In cultures from persons with sickling disorders, amounts of hemoglobin F that are known to inhibit sickling in vivo are produced. The results provide evidence that primitive erythroid progenitors are able to express the hemoglobin F production program and that cultures of mononuclear cells of the adult blood can be used to investigate the mechanisms involved in regulation of gamma-globin gene switching.

UI MeSH Term Description Entries
D012156 Reticulocytes Immature ERYTHROCYTES. In humans, these are ERYTHROID CELLS that have just undergone extrusion of their CELL NUCLEUS. They still contain some organelles that gradually decrease in number as the cells mature. RIBOSOMES are last to disappear. Certain staining techniques cause components of the ribosomes to precipitate into characteristic "reticulum" (not the same as the ENDOPLASMIC RETICULUM), hence the name reticulocytes. Reticulocyte
D002454 Cell Differentiation Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs. Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D005319 Fetal Hemoglobin The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA. Hemoglobin F,Hemoglobin, Fetal
D006412 Hematopoietic Stem Cells Progenitor cells from which all blood cells derived. They are found primarily in the bone marrow and also in small numbers in the peripheral blood. Colony-Forming Units, Hematopoietic,Progenitor Cells, Hematopoietic,Stem Cells, Hematopoietic,Hematopoietic Progenitor Cells,Cell, Hematopoietic Progenitor,Cell, Hematopoietic Stem,Cells, Hematopoietic Progenitor,Cells, Hematopoietic Stem,Colony Forming Units, Hematopoietic,Colony-Forming Unit, Hematopoietic,Hematopoietic Colony-Forming Unit,Hematopoietic Colony-Forming Units,Hematopoietic Progenitor Cell,Hematopoietic Stem Cell,Progenitor Cell, Hematopoietic,Stem Cell, Hematopoietic,Unit, Hematopoietic Colony-Forming,Units, Hematopoietic Colony-Forming
D006441 Hemoglobin A Normal adult human hemoglobin. The globin moiety consists of two alpha and two beta chains.
D006451 Hemoglobin, Sickle An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia. Hemoglobin S,Deoxygenated Sickle Hemoglobin,Deoxyhemoglobin S,Hemoglobin SS,Hemoglobin, Deoxygenated Sickle,SS, Hemoglobin,Sickle Hemoglobin,Sickle Hemoglobin, Deoxygenated
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000755 Anemia, Sickle Cell A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S. Hemoglobin S Disease,HbS Disease,Sickle Cell Anemia,Sickle Cell Disease,Sickle Cell Disorders,Sickling Disorder Due to Hemoglobin S,Anemias, Sickle Cell,Cell Disease, Sickle,Cell Diseases, Sickle,Cell Disorder, Sickle,Cell Disorders, Sickle,Disease, Hemoglobin S,Hemoglobin S Diseases,Sickle Cell Anemias,Sickle Cell Diseases,Sickle Cell Disorder

Related Publications

T Papayannopoulou, and B Nakamoto, and J Buckley, and S Kurachi, and P E Nute, and G Stamatoyannopoulos
FK228 Analogues Induce Fetal Hemoglobin in Human Erythroid Progenitors.
January 2012, Anemia,
T Papayannopoulou, and B Nakamoto, and J Buckley, and S Kurachi, and P E Nute, and G Stamatoyannopoulos
Human adipose tissue contains erythroid progenitors expressing fetal hemoglobin.
October 2013, World journal of stem cells,
T Papayannopoulou, and B Nakamoto, and J Buckley, and S Kurachi, and P E Nute, and G Stamatoyannopoulos
Stochastic expression of fetal hemoglobin in adult erythroid cells.
November 1981, Proceedings of the National Academy of Sciences of the United States of America,
T Papayannopoulou, and B Nakamoto, and J Buckley, and S Kurachi, and P E Nute, and G Stamatoyannopoulos
Mechanism for fetal hemoglobin induction by hydroxyurea in sickle cell erythroid progenitors.
November 2000, American journal of hematology,
T Papayannopoulou, and B Nakamoto, and J Buckley, and S Kurachi, and P E Nute, and G Stamatoyannopoulos
Selectively increased growth of fetal hemoglobin-expressing adult erythroid progenitors after brief treatment of early progenitors with transforming growth factor beta.
May 2000, Blood,
T Papayannopoulou, and B Nakamoto, and J Buckley, and S Kurachi, and P E Nute, and G Stamatoyannopoulos
Relationship between cell-cycle state of erythroid progenitors and fetal hemoglobin synthesis.
January 1992, American journal of hematology,
T Papayannopoulou, and B Nakamoto, and J Buckley, and S Kurachi, and P E Nute, and G Stamatoyannopoulos
Fetal hemoglobin production in cultures of primitive and mature human erythroid progenitors: differentiation affects the quantity of fetal hemoglobin produced per fetal-hemoglobin-containing cell.
June 1983, Blood,
T Papayannopoulou, and B Nakamoto, and J Buckley, and S Kurachi, and P E Nute, and G Stamatoyannopoulos
Cellular regulation of fetal hemoglobin synthesis in man. Investigation of gamma and beta mRNA accumulation in clonal erythroid cultures initiated from erythroid progenitors derived from fetuses, neonates, and adult individuals.
November 1980, Developmental biology,
T Papayannopoulou, and B Nakamoto, and J Buckley, and S Kurachi, and P E Nute, and G Stamatoyannopoulos
Circulating erythroid progenitors in the anemia of prematurity.
September 1987, The New England journal of medicine,
T Papayannopoulou, and B Nakamoto, and J Buckley, and S Kurachi, and P E Nute, and G Stamatoyannopoulos
Prostaglandin E2 mediated effects on the synthesis of fetal and adult hemoglobin in blood erythroid bursts.
April 1985, Prostaglandins,
Copied contents to your clipboard!