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Using the binding protein method we found that cAMP levels in normal, exponentially growing Euglena stay constant on per cell and protein basis. The level rises slightly when cells enter the stationary stage. Cells growing in low vitamin B12 medium show the same pattern during predeficiency growth. Upon becoming vitamin B12 deficient, the cAMP level decreases. Replenishment of these cells with the vitamin causes an immediate drop, followed by a sharp rise in cAMP. This is followed by resumption of DNA synthesis. The cAMP level drops and rises again when DNA duplication is completed and during the G2 period. The level of the cAMP drops again followed by resumption of cell division. the data suggest a relation exists between cAMP level, resumption and completion of DNA synthesis, and cell division.
E F Carell, and
K L Dearfield
January 1975,
In vitro,
E F Carell, and
K L Dearfield
August 1973,
Life sciences,
E F Carell, and
K L Dearfield
May 1975,
The Journal of biological chemistry,
E F Carell, and
K L Dearfield
August 1981,
Cancer research,
E F Carell, and
K L Dearfield
January 1977,
Oncology,
E F Carell, and
K L Dearfield
December 1973,
Proceedings of the National Academy of Sciences of the United States of America,
E F Carell, and
K L Dearfield
September 1978,
Molecular & general genetics : MGG,
E F Carell, and
K L Dearfield
January 1975,
Journal of the National Cancer Institute,
E F Carell, and
K L Dearfield
November 1981,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
E F Carell, and
K L Dearfield
January 1972,
Postepy biochemii,
