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Adult T-cell leukemia virus (ATLV) or ATLV-associated antigen (ATLA)-positive cell clones were isolated from peripheral blood lymphocytes of all five anti-ATLA-seropositive healthy adults tested by a limiting-dilution culture method in the presence of T-cell growth factor (TCGF) but from none of six seronegative adults similarly tested. Although ATLA-positive cells were not always detected in mass cultures of the seropositive lymphocytes, they were found consistently in T-cell cloned cultures of those lymphocytes. Continuous cultures of the ATLA-positive clones obtained were dependent on TCGF. Five clones derived from each of the five donors were maintained for greater than 4 months and, during culture, all of them acquired the ability to grow without added TCGF. The ATLA-positive clones formed rosettes with erythrocytes and expressed Leu 1, Leu 3a, and Leu 4 antigens but not Leu 2a antigen. These results indicate that anti-ATLA-seropositive healthy individuals carry ATLV in T cells circulating in their peripheral blood.
Y I Gotoh, and
K Sugamura, and
Y Hinuma
December 1987,
Fukuoka igaku zasshi = Hukuoka acta medica,
Y I Gotoh, and
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January 1983,
Progress in clinical and biological research,
Y I Gotoh, and
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August 1982,
Gan to kagaku ryoho. Cancer & chemotherapy,
Y I Gotoh, and
K Sugamura, and
Y Hinuma
June 1986,
Clinical and experimental immunology,
Y I Gotoh, and
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Y Hinuma
December 1986,
AIDS research,
Y I Gotoh, and
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Y Hinuma
October 1986,
Nihon rinsho. Japanese journal of clinical medicine,
Y I Gotoh, and
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Y Hinuma
January 1987,
Haematologica,
Y I Gotoh, and
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January 1986,
Japanese journal of cancer research : Gann,
Y I Gotoh, and
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Y Hinuma
March 1983,
The Journal of infectious diseases,
Y I Gotoh, and
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February 1983,
Gan to kagaku ryoho. Cancer & chemotherapy,
