Photochemotherapy of psoriasis (PUVA) without specialized equipment. 1978

J W Petrozzi, and A M Kligman

High intensity long ultraviolet light (UV-A) systems along with oral methoxsalen (8-methoxypsoralen [8-MOP]) have been dramatically successful in clearing long-standing psoriasis. Since this equipment is beyond the reach of many dermatologists, we have examined alternate ways of achieving the benefits of PUVA photochemotherapy. A total of 24 patients with psoriasis have been treated with ordinary fluorescent blacklights in a conventional Zimmerman cabinet. Fourteen patients' conditions (58%) were cleared completely and the conditions of three (12%) were more than 80% improved. We used higher doses of 8-MOP, starting with 50 mg, and increased the dosage further in 15 cases. In five instances, 80-mg levels were given. With certain modifications, it may be possible to attain satisfactory therapeutic results with ordinary equipment. Higher doses of 8-MOP may be necessary to compensate for the lower irradiance light source in some instances. However, wide-spread use of PUVA therapy cannot be recommended at this time until the long-term effects of this treatment become known.

UI MeSH Term Description Entries
D008730 Methoxsalen A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation. 8-Methoxypsoralen,Ammoidin,Xanthotoxin,8-MOP,Deltasoralen,Dermox,Geroxalen,Meladinina,Meladinine,Meloxine,Methoxa-Dome,Méladinine,Oxsoralen,Oxsoralen-Ultra,Puvalen,Ultramop,8 MOP,8 Methoxypsoralen,8MOP,Methoxa Dome,Oxsoralen Ultra
D010778 Photochemotherapy Therapy using oral or topical photosensitizing agents with subsequent exposure to light. Blue Light Photodynamic Therapy,Photodynamic Therapy,Red Light PDT,Red Light Photodynamic Therapy,Therapy, Photodynamic,Light PDT, Red,PDT, Red Light,Photochemotherapies,Photodynamic Therapies,Therapies, Photodynamic
D011565 Psoriasis A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis. Palmoplantaris Pustulosis,Pustular Psoriasis of Palms and Soles,Pustulosis Palmaris et Plantaris,Pustulosis of Palms and Soles,Psoriases
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

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