Biomaterial Database

Jejunal inhibition of gastric acid secretion induced by hypertonic glucose in duodenal ulcer patients before and after truncal vagotomy. 1978

J Christiansen, and P Aagaard, and T Hansen

The effect of intrajejunal infusion of hypertonic glucose on pentagastrin-stimulated (0.5 microgram/kg-hr) gastric acid secretion was studied in eight duodenal ulcer patients before and three to five months after truncal vagotomy. Preoperatively mean acid output was reduced from 44.0 +/- 3.1 meq H+/hr to 29.2 +/- 2.9 meq H+/hr (p less than 0.05), whereas no consistent changes were found postoperatively, suggesting that jejunal inhibition of gastric acid secretion induced by hypertonic glucose primarily is under vegal control. Furthermore, the study shows that glucose induced jejunal inhibition of acid secretion seems to be less pronouced in duodenal ulcer patients than previously found in healthy subjects.

UI	MeSH Term	Description	Entries
D007328	Insulin	A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).	Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D007583	Jejunum	The middle portion of the SMALL INTESTINE, between DUODENUM and ILEUM. It represents about 2/5 of the remaining portion of the small intestine below duodenum.	Jejunums
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010418	Pentagastrin	A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.	Acignost,Gastrin Pentapeptide,Peptavlon,Pentapeptide, Gastrin
D004381	Duodenal Ulcer	A PEPTIC ULCER located in the DUODENUM.	Curling's Ulcer,Curling Ulcer,Curlings Ulcer,Duodenal Ulcers,Ulcer, Curling,Ulcer, Duodenal,Ulcers, Duodenal
D005260	Female		Females
D005750	Gastric Juice	The liquid secretion of the stomach mucosa consisting of hydrochloric acid (GASTRIC ACID); PEPSINOGENS; INTRINSIC FACTOR; GASTRIN; MUCUS; and the bicarbonate ion (BICARBONATES). (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p651)	Gastric Juices,Juice, Gastric,Juices, Gastric
D005947	Glucose	A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.	Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D005950	Glucose Solution, Hypertonic	Solution that is usually 10 percent glucose but may be higher. An isotonic solution of glucose is 5 percent.	Hypertonic Glucose Solution,Hypertonic Solution, Glucose,Glucose Solutions, Hypertonic,Hypertonic Solutions, Glucose,Glucose Hypertonic Solution,Glucose Hypertonic Solutions,Hypertonic Glucose Solutions,Solution, Glucose Hypertonic,Solution, Hypertonic Glucose,Solutions, Glucose Hypertonic,Solutions, Hypertonic Glucose