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Changes in the myocardium arter numerous treatments with hyperbaric oxygenation (HBO) (PO2 3 technical atmospheres, time of saturation--45 min) were studied by morphological, histochemical and enzymohistochemical methods in 50 rabbits. Three stages were found to occur in the development of these changes: 1) functional-morphological changes (1--3 seanses of HBO), 2) early morphological changes (4--5 seanses), 3) marked morphological lesions (6--8 seanses). The first three treatments produce reversible changes on the part of metabolic processes (a reduction in the content of glycogen and changes in the activity of oxidoreductases: succinate-, malate- and lactate dehydrogenase). Morphological signs of oxygen toxicity in the form of disorders in hemodynamics and microcirculation, and dystrophy of cardiomyocytes appear after 4 seanses of HBO and increase with further treatment. The experimental data permit to recommend short HBO courses (1--3 seanses) for therapeutic application.
V V Rossinskaia, and
V N Shliapnikov, and
M V Uglova
August 1969,
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V V Rossinskaia, and
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V V Rossinskaia, and
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V V Rossinskaia, and
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M V Uglova
January 1970,
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V V Rossinskaia, and
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M V Uglova
July 1984,
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V V Rossinskaia, and
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November 1965,
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V V Rossinskaia, and
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M V Uglova
January 1975,
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V V Rossinskaia, and
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M V Uglova
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