Consequences of misrouting goldfish optic axons. 1983

J E Cook, and A J Pilgrim, and T J Horder

Cut optic axons regenerate into the goldfish tectum by indirect routes. To study the accuracy with which they terminate we made visuotectal maps before and immediately after cutting through the rostral tectum from its medial edge. This severed the normal pathway to medial tectum leaving intact only grossly misrouted axons. In fish mapped in this way, 3 months or more after contralateral optic nerve cuts, each initial map was essentially normal. After a tectal cut the electrical responses were usually weaker; but their receptive field positions proved to match very closely those noted previously for the same recording sites. The mean angular change was only 8.48 degrees and much of this could be accounted for by experimental errors. In fish mapped 6 months or more after attempts to cross-unite the optic tract brachia, initial maps were less regular. Some showed gross rearrangement of groups of terminals; and recognizable irregularities persisted in two fish mapped again after a further 4 or 5 months. However, maps made after tectal cuts in such fish were not noticeably less regular than the initial maps. Field position changes averaged 17.85 degrees. In both groups misrouted axons, filled with horseradish peroxidase after mapping and visualized in whole-mounts, crossed the tectum from lateral regions to reach the medial recording sites. The small field position changes in both groups confirm that axons from detectable terminals only among their retinal neighbours; nevertheless the irregular maps seen after tract cross-union lead us to expect the orderly arrangement of the normal pathway to contribute significantly to the precision of the normal map.

UI MeSH Term Description Entries
D009435 Synaptic Transmission The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES. Neural Transmission,Neurotransmission,Transmission, Neural,Transmission, Synaptic
D009900 Optic Nerve The 2nd cranial nerve which conveys visual information from the RETINA to the brain. The nerve carries the axons of the RETINAL GANGLION CELLS which sort at the OPTIC CHIASM and continue via the OPTIC TRACTS to the brain. The largest projection is to the lateral geniculate nuclei; other targets include the SUPERIOR COLLICULI and the SUPRACHIASMATIC NUCLEI. Though known as the second cranial nerve, it is considered part of the CENTRAL NERVOUS SYSTEM. Cranial Nerve II,Second Cranial Nerve,Nervus Opticus,Cranial Nerve, Second,Cranial Nerves, Second,Nerve, Optic,Nerve, Second Cranial,Nerves, Optic,Nerves, Second Cranial,Optic Nerves,Second Cranial Nerves
D003530 Cyprinidae A family of freshwater fish comprising the minnows or CARPS. Barbels,Chub,Dace,Minnows,Roach (Fish),Shiner,Tench,Tinca,Barbus,Rutilus rutilus,Tinca tinca,Chubs,Shiners,Tinca tincas,tinca, Tinca
D006054 Goldfish Common name for Carassius auratus, a type of carp (CARPS). Carassius auratus
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001369 Axons Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body. Axon
D013477 Superior Colliculi The anterior pair of the quadrigeminal bodies which coordinate the general behavioral orienting responses to visual stimuli, such as whole-body turning, and reaching. Colliculus, Superior,Optic Lobe, Human,Optic Lobe, Mammalian,Optic Tectum,Anterior Colliculus,Superior Colliculus,Tectum, Optic,Colliculi, Superior,Colliculus, Anterior,Human Optic Lobe,Human Optic Lobes,Mammalian Optic Lobe,Mammalian Optic Lobes,Optic Lobes, Human,Optic Lobes, Mammalian,Optic Tectums,Tectums, Optic
D014794 Visual Fields The total area or space visible in a person's peripheral vision with the eye looking straightforward. Field, Visual,Fields, Visual,Visual Field
D014796 Visual Perception The selecting and organizing of visual stimuli based on the individual's past experience. Visual Processing,Perception, Visual,Processing, Visual

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