-transparent.png){kind=logo}
The polyene antibiotic, amphotericin B, causes an acute reduction in renal blood flow and glomerular filtration rate. The purpose of this study was to evaluate the hypothesis that the renal vascular response to amphotericin B can be blocked by aminophylline. Toward this end, the effect of aminophylline on the renal response to amphotericin B in sodium-depleted dogs was examined. In dogs not treated with aminophylline, amphotericin B (0.5 mg/kg infused i.v. over 20 min) significantly reduced renal blood flow and glomerular filtration by 49.9 +/- 12.6 ml/min (mean +/- S.E.M.) and 23.4 +/- 2.4 ml/min, respectively at 140 min after the amphotericin B infusion. In dogs treated with an intrarenal aminophylline infusion (5 mg/min), the renal blood flow and glomerular filtration rate response to amphotericin B did not differ from that of amphotericin B vehicle. We conclude that aminophylline inhibits the renal response to amphotericin B. The possible clinical relevance of these observations are discussed.
J F Gerkens, and
H T Heidemann, and
E K Jackson, and
R A Branch
January 1993,
Revista do Hospital das Clinicas,
J F Gerkens, and
H T Heidemann, and
E K Jackson, and
R A Branch
January 1992,
The Journal of pharmacology and experimental therapeutics,
J F Gerkens, and
H T Heidemann, and
E K Jackson, and
R A Branch
August 1991,
Kidney international,
J F Gerkens, and
H T Heidemann, and
E K Jackson, and
R A Branch
January 1980,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
J F Gerkens, and
H T Heidemann, and
E K Jackson, and
R A Branch
August 1988,
American family physician,
J F Gerkens, and
H T Heidemann, and
E K Jackson, and
R A Branch
January 1990,
Drug safety,
J F Gerkens, and
H T Heidemann, and
E K Jackson, and
R A Branch
January 2002,
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia,
J F Gerkens, and
H T Heidemann, and
E K Jackson, and
R A Branch
February 2002,
The Journal of antimicrobial chemotherapy,
J F Gerkens, and
H T Heidemann, and
E K Jackson, and
R A Branch
July 1962,
The American journal of medicine,
J F Gerkens, and
H T Heidemann, and
E K Jackson, and
R A Branch
January 2002,
Nephrologie,
