Biomaterial Database

A comparison of the effects of dietary calcium and phosphorus deficiency on the in vitro and in vivo metabolism of 25-hydroxycholecalciferol in the chick. 1978

B A Sommerville, and R Swaminathan, and A D Care

1. Young chicks fed a diet deficient in calcium showed an eightfold increase in the in vitro renal production of 1,25-dihydroxycholecalciferol (1,25-DHCC) and those fed a diet deficient in phosphorus showed a threefold increase when compared to chicks on a normal diet. 2. The in vivo accumulation of 1,25-DHCC in the gut mucosa was doubled in both low-Ca and low-P groups as was the rate of Ca absorption from the duodenum and the Ca-binding protein activity. The accumulation of 1,25-DHCC in bone increased threefold in the low-Ca group but showed no change in the low-P group. 3. It was concluded that the increased rate of Ca absorption found in dietary P deficiency depends rather upon the capacity of the gut mucosa to accumulate larger amounts of 1,25-DHCC than upon an increased renal production of this metabolite. The mechanism by which this is achieved is unknown, but it unlikely to be a general increase in availability of 1,25-DHCC since no rise occurred in bone 1,25-DHCC levels.

UI	MeSH Term	Description	Entries
D007408	Intestinal Absorption	Uptake of substances through the lining of the INTESTINES.	Absorption, Intestinal
D008297	Male		Males
D010758	Phosphorus	A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.	Black Phosphorus,Phosphorus-31,Red Phosphorus,White Phosphorus,Yellow Phosphorus,Phosphorus 31,Phosphorus, Black,Phosphorus, Red,Phosphorus, White,Phosphorus, Yellow
D011485	Protein Binding	The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.	Plasma Protein Binding Capacity,Binding, Protein
D002118	Calcium	A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.	Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D002136	Calcium, Dietary	Calcium compounds in DIETARY SUPPLEMENTS or in food that supply the body with calcium.	Dietary Calcium
D002645	Chickens	Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.	Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D006887	Hydroxycholecalciferols	Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.	Hydroxyvitamins D,Hydroxycholecalciferol
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In