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XC cell line was established from a rat fibrosarcoma induced by avian sarcoma virus. Analysis of ribosomal RNA genes in the DNA of this cell line indicated that there was a 3- to 4-fold increase in the number of the rDNA repeating units. [methyl-14C]Methionine labeling experiments as well as Southern blot analysis of the restriction endonuclease fragments showed extensive methylation of the cytosine residues in the rDNA. Further analysis by HpaII, HhaI and MspI suggested that the entire rDNA repeat unit was uniformly methylated in the recognition sequence for these enzymes. Parallel experiments with two other rat cell lines (rat embryo fibroblasts and adenovirus-transformed rat embryo cells) indicated no evidence of methylation in the rDNA.
R A Katz, and
B F Erlanger, and
R V Guntaka
February 1982,
Cancer genetics and cytogenetics,
R A Katz, and
B F Erlanger, and
R V Guntaka
July 1982,
Nucleic acids research,
R A Katz, and
B F Erlanger, and
R V Guntaka
January 1982,
DNA (Mary Ann Liebert, Inc.),
R A Katz, and
B F Erlanger, and
R V Guntaka
January 1981,
Proceedings of the National Academy of Sciences of the United States of America,
R A Katz, and
B F Erlanger, and
R V Guntaka
March 1975,
Experimental cell research,
R A Katz, and
B F Erlanger, and
R V Guntaka
January 1984,
Current topics in microbiology and immunology,
R A Katz, and
B F Erlanger, and
R V Guntaka
February 1977,
Biochimica et biophysica acta,
R A Katz, and
B F Erlanger, and
R V Guntaka
February 1979,
Chromosoma,
R A Katz, and
B F Erlanger, and
R V Guntaka
January 1986,
FEBS letters,
R A Katz, and
B F Erlanger, and
R V Guntaka
August 1983,
Nucleic acids research,
