-transparent.png){kind=logo}
In addition to releasing collagenase and proteoglycanase activity, rabbit articular chondrocytes in monolayer culture released into the culture medium, latent, neutral enzyme activity which when activated by p-aminophenylmercuric acetate degraded fluorescein-labeled polymeric rat tail tendon Type I collagen and the tropocollagen TCA and TCB fragments of human Type II collagen into smaller peptides at 37 degrees C. Enzyme activity was abolished if p-aminophenylmercuric acetate-activated culture medium was preincubated with 1.10-phenanthroline, a metal chelator. Thus, articular chondrocytes in monolayer culture are capable of producing neutral proteinases which acting together can result in complete degradation of tendon and cartilage collagen to small peptides.
A I Sapolsky, and
M F Sheff, and
K Matsuta, and
D S Howell, and
R W Moskowitz, and
V M Goldberg, and
D P Norby, and
C J Malemud
January 1970,
Arthritis and rheumatism,
A I Sapolsky, and
M F Sheff, and
K Matsuta, and
D S Howell, and
R W Moskowitz, and
V M Goldberg, and
D P Norby, and
C J Malemud
October 1984,
Clinical orthopaedics and related research,
A I Sapolsky, and
M F Sheff, and
K Matsuta, and
D S Howell, and
R W Moskowitz, and
V M Goldberg, and
D P Norby, and
C J Malemud
June 1979,
The Journal of laboratory and clinical medicine,
A I Sapolsky, and
M F Sheff, and
K Matsuta, and
D S Howell, and
R W Moskowitz, and
V M Goldberg, and
D P Norby, and
C J Malemud
April 2013,
Osteoarthritis and cartilage,
A I Sapolsky, and
M F Sheff, and
K Matsuta, and
D S Howell, and
R W Moskowitz, and
V M Goldberg, and
D P Norby, and
C J Malemud
January 1972,
Endocrinology,
A I Sapolsky, and
M F Sheff, and
K Matsuta, and
D S Howell, and
R W Moskowitz, and
V M Goldberg, and
D P Norby, and
C J Malemud
February 2004,
International journal of molecular medicine,
A I Sapolsky, and
M F Sheff, and
K Matsuta, and
D S Howell, and
R W Moskowitz, and
V M Goldberg, and
D P Norby, and
C J Malemud
April 1995,
Biochimica et biophysica acta,
A I Sapolsky, and
M F Sheff, and
K Matsuta, and
D S Howell, and
R W Moskowitz, and
V M Goldberg, and
D P Norby, and
C J Malemud
January 1974,
Connective tissue research,
A I Sapolsky, and
M F Sheff, and
K Matsuta, and
D S Howell, and
R W Moskowitz, and
V M Goldberg, and
D P Norby, and
C J Malemud
August 1993,
In vitro cellular & developmental biology. Animal,
A I Sapolsky, and
M F Sheff, and
K Matsuta, and
D S Howell, and
R W Moskowitz, and
V M Goldberg, and
D P Norby, and
C J Malemud
October 1985,
Biochimica et biophysica acta,
