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The avian secondary palate exhibits the unique feature of a midline cleft. Cryostat sections indicated that although extensive contact between homologous shelves was present, chick palatal medial edge epithelium (MEE) failed to fuse. The failure of fusion and subsequent clefting of the avian palate were correlated with continued proliferation of the avian MEE, a failure of selective MEE cell death, and an absence of elevated levels of intracellular cAMP. Moreover, immunohistochemical staining for cAMP and microspectrophotometric quantitation of staining intensity indicated that staining of chick MEE was significantly (p less than .01) less than murine MEE at comparable gestational ages. These data indicate that differentiation of the avian secondary palate is fundamentally different than reported for the mammalian palate in that many developmental events known to be associated with normal mammalian palate formation (cessation of MEE proliferation, MEE cell death, elevated levels of MEE cAMP) fail to occur in the chick. The developing avian secondary palate, with its midline cleft, thus provides an interesting and useful model system with which to compare mammalian palate formation where the palate is normally fused in the midline.
R M Greene, and
R M Shah, and
M R Lloyd, and
B J Crawford, and
R Suen, and
J L Shanfeld, and
Z Davidovitch
January 1985,
Progress in clinical and biological research,
R M Greene, and
R M Shah, and
M R Lloyd, and
B J Crawford, and
R Suen, and
J L Shanfeld, and
Z Davidovitch
January 1988,
The Cleft palate journal,
R M Greene, and
R M Shah, and
M R Lloyd, and
B J Crawford, and
R Suen, and
J L Shanfeld, and
Z Davidovitch
January 1981,
Archives of oral biology,
R M Greene, and
R M Shah, and
M R Lloyd, and
B J Crawford, and
R Suen, and
J L Shanfeld, and
Z Davidovitch
January 1990,
The American journal of anatomy,
R M Greene, and
R M Shah, and
M R Lloyd, and
B J Crawford, and
R Suen, and
J L Shanfeld, and
Z Davidovitch
September 1974,
Actualites odonto-stomatologiques,
R M Greene, and
R M Shah, and
M R Lloyd, and
B J Crawford, and
R Suen, and
J L Shanfeld, and
Z Davidovitch
January 1970,
Acta stomatologica Belgica,
R M Greene, and
R M Shah, and
M R Lloyd, and
B J Crawford, and
R Suen, and
J L Shanfeld, and
Z Davidovitch
March 1980,
Nederlands tijdschrift voor tandheelkunde,
R M Greene, and
R M Shah, and
M R Lloyd, and
B J Crawford, and
R Suen, and
J L Shanfeld, and
Z Davidovitch
June 2008,
Journal of veterinary dentistry,
R M Greene, and
R M Shah, and
M R Lloyd, and
B J Crawford, and
R Suen, and
J L Shanfeld, and
Z Davidovitch
February 2007,
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology,
R M Greene, and
R M Shah, and
M R Lloyd, and
B J Crawford, and
R Suen, and
J L Shanfeld, and
Z Davidovitch
January 1976,
Acta anatomica,
