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The kinetics of 99mTechnetium pertechnetate (99mTcO-4) in the rabbit knee-joint were studied by external counting of the radio-isotope after intravenous injection. We studied joints with antigen-induced arthritis in the acute and chronic phase of joint inflammation as well as non-inflamed joints. In both inflamed and non-inflamed joints, a rapid increase in radioactivity was followed by a plateau lasting for at least one hour. The time needed to reach 95% of the plateau count rate (tp) was significantly increased in inflamed as compared with non-inflamed knee-joints. Moreover, tp values were significantly higher in acutely than in chronically inflamed joints. No correlation was found between 99mTcO1 uptake and tp values. The study of kinetics of 99mTcO-4 in the rabbit knee-joint provides information additional to quantitation of inflammation by 99mTcO-1 uptake measurements, since kinetic data characterize the type of joint inflammation.
H J van Beusekom, and
L B van de Putte, and
W C Buijs, and
W J van den Broek, and
W B van den Berg
January 1978,
Scandinavian journal of rheumatology,
H J van Beusekom, and
L B van de Putte, and
W C Buijs, and
W J van den Broek, and
W B van den Berg
January 1980,
Arzneimittel-Forschung,
H J van Beusekom, and
L B van de Putte, and
W C Buijs, and
W J van den Broek, and
W B van den Berg
January 1978,
Scandinavian journal of rheumatology,
H J van Beusekom, and
L B van de Putte, and
W C Buijs, and
W J van den Broek, and
W B van den Berg
April 1978,
Arthritis and rheumatism,
H J van Beusekom, and
L B van de Putte, and
W C Buijs, and
W J van den Broek, and
W B van den Berg
November 1969,
Annals of the rheumatic diseases,
H J van Beusekom, and
L B van de Putte, and
W C Buijs, and
W J van den Broek, and
W B van den Berg
March 2002,
Sao Paulo medical journal = Revista paulista de medicina,
H J van Beusekom, and
L B van de Putte, and
W C Buijs, and
W J van den Broek, and
W B van den Berg
February 2001,
British journal of pharmacology,
H J van Beusekom, and
L B van de Putte, and
W C Buijs, and
W J van den Broek, and
W B van den Berg
January 1980,
The Journal of rheumatology,
H J van Beusekom, and
L B van de Putte, and
W C Buijs, and
W J van den Broek, and
W B van den Berg
January 2011,
Hellenic journal of nuclear medicine,
H J van Beusekom, and
L B van de Putte, and
W C Buijs, and
W J van den Broek, and
W B van den Berg
January 1985,
Journal of orthopaedic research : official publication of the Orthopaedic Research Society,
