Biomaterial Database

[Value of the cytologic and biochemical study of alveolar lavage fluid in the evaluation of the developmental ability of sarcoidosis]. 1983

P Leclerc, and D Duchassaing, and M Cambillau, and F Capron

To study indicators of disease activity in sarcoidosis, bronchoalveolar lavage (BAL) and serum angiotensin-converting enzyme (SACE) measurement were performed in 39 patients with active sarcoidosis and in 13 patients with inactive sarcoidosis. All patients were non-smokers. Results were compared to those from 9 non-smoking controls and 20 patients with non-granulomatous interstitial lung disease. Lymphocyte counts, IgG concentrations and the IgG/K ratio were high in BAL fluid specimens from patients with active sarcoidosis, indicating a relationship between cellular and humoral immunity. Conversely, specimens from inactive sarcoidosis patients showed supranormal lymphocyte counts with IgG levels and a IgG/K ratio that did not differ significantly from those in controls or patients with interstitial lung disease (p greater than 0,05). Patients with active sarcoidosis that abated after 6 to 12 months had an initial lymphocytosis of 28.7% and a IgG/K ratio under 170 mg/mmol. We conclude that IgG concentrations and the IgG/K ratio are better discriminators between active and non-active or nearly resolved disease than lymphocyte counts. SACE assay is not sufficiently discriminative.

UI	MeSH Term	Description	Entries
D007507	Therapeutic Irrigation	The washing of a body cavity or surface by flowing water or solution for therapy or diagnosis.	Douching,Lavage,Douchings,Irrigation, Therapeutic,Irrigations, Therapeutic,Lavages,Therapeutic Irrigations
D008171	Lung Diseases	Pathological processes involving any part of the LUNG.	Pulmonary Diseases,Disease, Pulmonary,Diseases, Pulmonary,Pulmonary Disease,Disease, Lung,Diseases, Lung,Lung Disease
D011650	Pulmonary Alveoli	Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.	Alveoli, Pulmonary,Alveolus, Pulmonary,Pulmonary Alveolus
D001826	Body Fluids	Liquid components of living organisms.	Body Fluid,Fluid, Body,Fluids, Body
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D012507	Sarcoidosis	An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.	Besnier-Boeck Disease,Boeck's Sarcoid,Besnier-Boeck-Schaumann Syndrome,Boeck Disease,Boeck's Disease,Schaumann Disease,Schaumann Syndrome,Schaumann's Syndrome,Besnier Boeck Disease,Besnier Boeck Schaumann Syndrome,Boeck Sarcoid,Boecks Disease,Boecks Sarcoid,Disease, Schaumann,Sarcoid, Boeck's,Sarcoidoses,Schaumann's Syndromes,Syndrome, Besnier-Boeck-Schaumann,Syndrome, Schaumann,Syndrome, Schaumann's
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor