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In an effort to prevent cytomegalovirus infection among seronegative patients having marrow transplants, a globulin with high antibody levels against cytomegalovirus was given before and for 11 weeks after transplantation in a randomized trial. Among 36 patients who received no prophylactic granulocyte transfusions, globulin recipients had significantly fewer infections than controls (2 of 17 versus 8 of 19, p = 0.05 by Fisher's exact test and p = 0.03 by Mantel-Cox test). Conversely, infection rates were high and unchanged by globulin use among patients who received granulocytes from seropositive donors (7 of 8 recipients versus 6 of 7 controls). The lack of effect of the globulin among patients receiving transfusions of granulocytes from seropositive donors may suggest that the dose of antibody was insufficient or that antibody is ineffective against virus transmitted in granulocytes. We conclude that cytomegalovirus infection can be prevented by immunoprophylaxis in seronegative patients having marrow transplants who are not given granulocyte transfusions.
J D Meyers, and
J Leszczynski, and
J A Zaia, and
N Flournoy, and
B Newton, and
D R Snydman, and
G G Wright, and
M J Levin, and
E D Thomas
January 1987,
Annals of internal medicine,
J D Meyers, and
J Leszczynski, and
J A Zaia, and
N Flournoy, and
B Newton, and
D R Snydman, and
G G Wright, and
M J Levin, and
E D Thomas
April 1986,
The New England journal of medicine,
J D Meyers, and
J Leszczynski, and
J A Zaia, and
N Flournoy, and
B Newton, and
D R Snydman, and
G G Wright, and
M J Levin, and
E D Thomas
January 1989,
Reviews of infectious diseases,
J D Meyers, and
J Leszczynski, and
J A Zaia, and
N Flournoy, and
B Newton, and
D R Snydman, and
G G Wright, and
M J Levin, and
E D Thomas
December 1989,
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J D Meyers, and
J Leszczynski, and
J A Zaia, and
N Flournoy, and
B Newton, and
D R Snydman, and
G G Wright, and
M J Levin, and
E D Thomas
March 1988,
Bone marrow transplantation,
J D Meyers, and
J Leszczynski, and
J A Zaia, and
N Flournoy, and
B Newton, and
D R Snydman, and
G G Wright, and
M J Levin, and
E D Thomas
October 1987,
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J D Meyers, and
J Leszczynski, and
J A Zaia, and
N Flournoy, and
B Newton, and
D R Snydman, and
G G Wright, and
M J Levin, and
E D Thomas
December 2019,
Clinical transplantation,
J D Meyers, and
J Leszczynski, and
J A Zaia, and
N Flournoy, and
B Newton, and
D R Snydman, and
G G Wright, and
M J Levin, and
E D Thomas
October 1986,
Gematologiia i transfuziologiia,
J D Meyers, and
J Leszczynski, and
J A Zaia, and
N Flournoy, and
B Newton, and
D R Snydman, and
G G Wright, and
M J Levin, and
E D Thomas
April 1985,
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J D Meyers, and
J Leszczynski, and
J A Zaia, and
N Flournoy, and
B Newton, and
D R Snydman, and
G G Wright, and
M J Levin, and
E D Thomas
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