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The correlation between phosphate metabolism and isometric contraction was investigated in helical strips from dog coronary artery. Adenosine triphosphate (ATP) and creatine phosphate (CP) contents of resting strips did not significantly change during anoxia. ATP content remained unchanged during potassium-contracture under aerobic conditions but was significantly reduced by anoxia. Pretreatment with iodoacetate resulted in a striking reduction in ATP content with a less marked decrease in CP content. ATP-depleting effect of iodoacetate was reduced slightly by the addition of pyruvate, but contractile response was not restored. It is considered that high-energy phosphates provided by anaerobic glycolysis can meet the energy requirements of resting coronary vessels but are insufficient for maintaining active tension. In resting strips equilibrated for 2 h in oxygenated bath solution, the reactivity to KCl and anoxia appears to be dependent on the availability of ATP.
F Takenaka, and
M Sakanashi, and
M Higuchi
April 1985,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
F Takenaka, and
M Sakanashi, and
M Higuchi
February 1982,
Japanese journal of pharmacology,
F Takenaka, and
M Sakanashi, and
M Higuchi
October 1986,
Magnetic resonance in medicine,
F Takenaka, and
M Sakanashi, and
M Higuchi
April 1975,
The American journal of cardiology,
F Takenaka, and
M Sakanashi, and
M Higuchi
October 1973,
Archives internationales de pharmacodynamie et de therapie,
F Takenaka, and
M Sakanashi, and
M Higuchi
May 1969,
The American journal of physiology,
F Takenaka, and
M Sakanashi, and
M Higuchi
January 1965,
Archivio di scienze biologiche,
F Takenaka, and
M Sakanashi, and
M Higuchi
January 1985,
Annual review of physiology,
F Takenaka, and
M Sakanashi, and
M Higuchi
January 1963,
Physiologia bohemoslovenica,
F Takenaka, and
M Sakanashi, and
M Higuchi
May 1993,
Japanese journal of pharmacology,
